Publication Name	World Journal of Gastroenterology
Manuscript ID	28549
Country	China

Received	2016-07-05 11:35
Peer-Review Started	2016-07-06 18:27
To Make the First Decision	2016-08-29 08:32
Return for Revision	2016-08-31 09:16
Revised	2016-09-11 20:51
Second Decision	2016-09-21 15:01
Accepted by Journal Editor-in-Chief	2016-09-21 16:08
Accepted by Executive Editor-in-Chief	2016-09-28 18:53
Articles in Press	2016-09-28 18:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-10-15 02:55
Typeset the Manuscript	2016-11-21 00:38
Publish the Manuscript Online	2016-11-26 18:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury
Manuscript Source	Unsolicited Manuscript
All Author List	Chao Wang, Rui-Qin Fan, Yan-Xiang Zhang, Hao Nie and Kan Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31502059 Education Department of Hubei Province B2016039 Medical School of Yangtze University YXYQ201406 Clinical and Molecular Immunology Research Center of Yangtze University
Corresponding Author	Dr. Chao Wang, Associate Professor, Department of Laboratory Medicine, Medical School, Yangtze University, 1 Nanhuan Road, Jingzhou 434023, Hubei Province, China. celful60@163.com
Key Words	Naringenin; Isoniazid; Rifampicin; Oxidative stress; Apoptosis; Hepatic injury
Core Tip	Anti-tuberculosis drugs can cause drug-induced liver injury through a series of complex mechanisms. The main purposes of the study were to explore the effects of naringenin (NRG) on liver injury induced by isoniazid (INH) and rifampicin (RIF). Mice were administered intragastrically with NRG before INH and RIF challenge. The findings revealed that NRG protects against INH- and RIF-induced oxidative stress and hepatocyte apoptosis.
Publish Date	2016-11-26 18:57
Citation	Wang C, Fan RQ, Zhang YX, Nie H, Li K. Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury. World J Gastroenterol 2016; 22(44): 9775-9783
URL	http://www.wjgnet.com/1007-9327/full/v22/i44/9775.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i44.9775

Full Article (PDF)	WJG-22-9775.pdf
Full Article (Word)	WJG-22-9775.doc
Manuscript File	28549-Review.doc
Answering Reviewers	28549-Answering reviewers.pdf
Audio Core Tip	28549-Audio core tip.mp3
Biostatistics Review Certificate	28549-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28549-Conflict-of-interest statement.pdf
Copyright License Agreement	28549-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28549-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	28549-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	28549-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28549-Language certificate.pdf
Peer-review Report	28549-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28549-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28549-Scientific misconduct check.pdf
Scientific Editor Work List	28549-Scientific editor work list.pdf