Publication Name	World Journal of Gastroenterology
Manuscript ID	28607
Country	Netherlands

Received	2016-07-07 08:49
Peer-Review Started	2016-07-09 18:43
To Make the First Decision	2016-09-12 16:41
Return for Revision	2016-09-13 17:24
Revised	2016-11-16 06:30
Second Decision	2017-01-06 13:58
Accepted by Journal Editor-in-Chief	2017-01-08 17:13
Accepted by Executive Editor-in-Chief	2017-01-11 12:04
Articles in Press	2017-01-11 12:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-13 21:07
Publish the Manuscript Online	2017-01-22 11:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Current and future therapies for inherited cholestatic liver diseases
Manuscript Source	Invited Manuscript
All Author List	Wendy L van der Woerd, Roderick HJ Houwen and Stan FJ van de Graaf
Funding Agency and Grant Number
Corresponding Author	Wendy L van der Woerd, MD, PhD, Department of Pediatric Gastroenterology, Wilhelmina Children’s Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands. wwoerd@umcutrecht.nl
Key Words	Familial intrahepatic cholestasis; Progressive familial intrahepatic cholestasis; Inherited liver disease; ATP8B1; ABCB11; ABCB4; Biliary diversion; Mutation-targeted therapy; Personalized treatment
Core Tip	Familial intrahepatic cholestasis (FIC) is a group of autosomal recessive liver diseases charac-terized by intrahepatic cholestasis. Phenotypes vary from only episodic disease to progressive FIC. Current therapeutic options are often insufficient to prevent progression of the disease. This review will discuss the current therapeutic regimen as well as the development of novel therapeutic strategies, focusing on surgical and pharmacological biliary diversion, hepatocyte transplantation and mutation-specific therapy.
Publish Date	2017-01-22 11:39
Citation	van der Woerd WL, Houwen RHJ, van de Graaf SFJ. Current and future therapies for inherited cholestatic liver diseases. World J Gastroenterol 2017; 23(5): 763-775
URL	http://www.wjgnet.com/1007-9327/full/v23/i5/763.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i5.763

Full Article (PDF)	WJG-23-763.pdf
Full Article (Word)	WJG-23-763.doc
Manuscript File	28607-Review.doc
Answering Reviewers	28607-Answering reviewers.pdf
Audio Core Tip	28607-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28607-Conflict-of-interest statement.pdf
Copyright License Agreement	28607-Copyright assignment.pdf
Peer-review Report	28607-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28607-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28607-Scientific misconduct check.pdf
Scientific Editor Work List	28607-Scientific editor work list.pdf