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Articles Published Processes
12/6/2016 5:24:00 PM | Browse: 1060 | Download: 2252
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Received |
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2016-07-08 08:41 |
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Peer-Review Started |
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2016-07-12 17:49 |
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To Make the First Decision |
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2016-07-29 16:27 |
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Return for Revision |
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2016-08-02 16:56 |
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Revised |
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2016-10-02 19:57 |
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Second Decision |
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2016-11-07 09:20 |
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Accepted by Journal Editor-in-Chief |
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2016-11-07 21:12 |
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Accepted by Executive Editor-in-Chief |
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2016-11-13 15:31 |
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Articles in Press |
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2016-11-13 15:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-23 16:09 |
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Publish the Manuscript Online |
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2016-12-06 17:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Corrado Pedrazzani, Guido Mantovani, Gian Luca Salvagno, Elisabeth Baldiotti, Andrea Ruzzenente, Calogero Iacono, Giuseppe Lippi and Alfredo Guglielmi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Corrado Pedrazzani, MD, Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Scuro 10, 37134 Verona,
Italy. corrado.pedrazzani@univr.it |
| Key Words |
Colorectal cancer; Fibrinogen; Tumour markers; Prognosis; Colorectal surgery |
| Core Tip |
Fibrinogen is involved in tumourigenesis and in tumour progression in several malignancies. Many studies, particularly from East, have shown a correlation between hyperfibrinogenemia and poor prognosis in patients with colorectal cancer (CRC). This study involves a large cohort of 652 Western patients underwent surgery for CRC. The analysis of our data demonstrates that preoperative fibrinogen plasma levels correlate with leading prognostic factors in patients undergoing surgery for CRC. Although long-term survival and tumour-related survival are worse in patients with hyperfibrinogenemia, these findings are not confirmed in multivariate analysis or after stratification of patients according to completeness of tumour resection and TNM stage.
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| Publish Date |
2016-12-06 17:24 |
| Citation |
Pedrazzani C, Mantovani G, Salvagno GL, Baldiotti E, Ruzzenente A, Iacono C, Lippi G, Guglielmi A. Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer. World J Gastroenterol 2016; 22(45): 9994-10001 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i45/9994.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i45.9994 |
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