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Articles Published Processes
11/6/2016 3:43:00 PM | Browse: 1239 | Download: 1578
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Received |
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2016-07-09 12:16 |
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Peer-Review Started |
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2016-07-12 19:42 |
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To Make the First Decision |
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2016-07-29 16:27 |
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Return for Revision |
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2016-08-02 17:34 |
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Revised |
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2016-08-25 05:02 |
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Second Decision |
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2016-09-21 15:02 |
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Accepted by Journal Editor-in-Chief |
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2016-09-21 15:29 |
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Accepted by Executive Editor-in-Chief |
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2016-09-28 18:56 |
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Articles in Press |
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2016-09-28 18:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-01 10:13 |
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Publish the Manuscript Online |
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2016-11-06 15:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Angela C Baird, Dominic Mallon, Graham Radford-Smith, Julien Boyer, Thierry Piche, Susan L Prescott, Ian C Lawrance and Meri K Tulic |
| Funding Agency and Grant Number |
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| Corresponding Author |
Meri K Tulic, PhD, INSERM, CR1, Professor, Mediterranean Center for Molecular Medicine (C3M)-INSERM U1065, Team 12, Batiment Archimed, 151 route Saint-Antoine de Ginestiere, 06204 Nice,
France. meri.tulic@unice.fr
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| Key Words |
Ulcerative colitis; Innate immunity; Anti-tumor necrosis factor therapy; Toll-like receptor; IRAK4; Inflammatory bowel disease |
| Core Tip |
anti-tumor necrosis factor (TNF) therapy is effective in approximately 60% of ulcerative colitis (UC) patients. Currently we do not know which patients are likely to benefit from this costly treatment. Here we show that differences in innate immune function [measured by patients response to toll-like-receptor (TLR), TLR agonists] exist between UC responders and non-responders. Differences exist in (1) content of immune and regulatory cells in their blood; (2) capacity of their cells to produce cytokines; and (3) in their signalling following TLR activation. Serological measure of TLR function may prove to be a useful tool in clinic to predict patient’s response to anti-TNF treatment. |
| Publish Date |
2016-11-06 15:43 |
| Citation |
Baird AC, Mallon D, Radford-Smith G, Boyer J, Piche T, Prescott SL, Lawrance IC, Tulic MK. Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy. World J Gastroenterol 2016; 22(41): 9104-9116 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9104.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9104 |
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