Publication Name	World Journal of Diabetes
Manuscript ID	28682
Country	India

Received	2016-07-11 09:22
Peer-Review Started	2016-07-14 18:24
First Decision by Editorial Office Director
Return for Revision	2016-09-12 15:27
Revised	2016-09-26 22:52
Publication Fee Transferred
Second Decision by Editor	2016-11-10 14:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-11-22 15:35
Articles in Press	2016-11-22 15:35
Edit the Manuscript by Language Editor	2016-12-21 14:51
Typeset the Manuscript	2017-03-07 09:28
Publish the Manuscript Online	2017-03-09 16:09

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Prospective Study
Article Title	Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients
Manuscript Source	Invited Manuscript
All Author List	Neerja Aggarwal, Pawan Kumar Kare, Parul Varshney, Om Prakash Kalra, Sri Venkata Madhu, Basu Dev Banerjee, Anil Yadav, Alpana Raizada and Ashok Kumar Tripathi
Funding Agency and Grant Number	Funding Agency Grant Number Department of Biotechnology, Government of India, New Delhi (DBT Project) BT/PR 4640/MED/30/716/2012
Corresponding Author	Ashok Kumar Tripathi, PhD, Professor, Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India. aktripathiucms@gmail.com
Key Words	Diabetic nephropathy; Angiotensin converting enzyme inhibitor therapy; Renin-angiotensin-aldosterone system gene polymorphisms; Responder; Urinary albumin/creatinine ratio; Albuminuria
Core Tip	Angiotensin converting enzyme (ACE) inhibitors are used as standard therapy in patients with diabetic nephropathy (DN) and reported to have reno-protective effect in these patients; however, the response to ACE inhibitor therapy is not uniform in all patients. We investigated whether ACE I/D and angiotensinogen gene (AGT) M235T polymorphisms of genes of the renin-angiotensin-aldosterone system are associated with variable response to ACE inhibitors in DN patients. ACE inhibitor treatment in DN patients caused a significant reduction in urinary protein excretion and was found independent of ACE I/D and AGT M235T polymorphisms.
Publish Date	2017-03-09 16:09
Citation	Aggarwal N, Kare PK, Varshney P, Kalra OP, Madhu SV, Banerjee BD, Yadav A, Raizada A, Tripathi AK. Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients. World J Diabetes 2017; 8(3): 112-119
URL	http://www.wjgnet.com/1948-9358/full/v8/i3/112.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i3.112

Full Article (PDF)	WJD-8-112.pdf
Full Article (Word)	WJD-8-112.doc