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1/12/2017 1:49:00 PM | Browse: 913 | Download: 1731
Publication Name World Journal of Gastroenterology
Manuscript ID 28708
Country France
Received
2016-07-12 09:25
Peer-Review Started
2016-07-13 17:05
To Make the First Decision
2016-08-29 08:44
Return for Revision
2016-09-02 10:06
Revised
2016-09-06 23:28
Second Decision
2016-09-21 15:50
Accepted by Journal Editor-in-Chief
2016-09-24 15:20
Accepted by Company Editor-in-Chief
2016-09-28 18:00
Articles in Press
2016-09-28 18:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-01-01 16:21
Publish the Manuscript Online
2017-01-12 13:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging
Manuscript Source Unsolicited Manuscript
All Author List Rachel Marion-Letellier, Pierre Bohn, Romain Modzelewski, Pierre Vera, Moutaz Aziz, Charlène Guérin, Guillaume Savoye and Céline Savoye-Collet
Funding Agency and Grant Number
Corresponding Author Dr. Rachel Marion-Letellier, PhD, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, 76183 Rouen, France. marion_rachel@hotmail.com
Key Words Crohn’s disease; Colitis; Colitis imaging; Cyclooxygenase-2; SPECT-computed tomography
Core Tip Transsectional imaging such as magnetic resonance imaging are emerging to evaluate colonic inflammation but they do not allowed inflammation quantification. Functional imaging by SPECT-computed tomography (CT) could be interesting under quanti-fication. This present study validates the use of SPECT in colitis models. We confronted SPECT-CT parameters to lab parameters and we found that maximal thickness was correlated to inflammatory parameters such as colon COX-2 expression or histological inflammatory score. Evaluating animal models may be important an important tool for preclinical studies in inflammatory bowel diseases models. It also allows optimizing the technique prior to patient contact.
Publish Date 2017-01-12 13:49
Citation Marion-Letellier R, Bohn P, Modzelewski R, Vera P, Aziz M, Guérin C, Savoye G, Savoye-Collet C. SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World J Gastroenterol 2017; 23(2): 216-223
URL http://www.wjgnet.com/1007-9327/full/v23/i2/216.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i2.216
Full Article (PDF) WJG-23-216.pdf
Full Article (Word) WJG-23-216.doc
Manuscript File 28708-Review.docx
Answering Reviewers 28708-Answering reviewers.pdf
Audio Core Tip 28708-Audio core tip.m4a
Biostatistics Review Certificate 28708-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28708-Conflict-of-interest statement.pdf
Copyright License Agreement 28708-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 28708-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 28708-Institutional review board statement.pdf
Peer-review Report 28708-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28708-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28708-Scientific misconduct check.pdf
Scientific Editor Work List 28708-Scientific editor work list.pdf