Publication Name	World Journal of Hepatology
Manuscript ID	28711
Country	Brazil

Received	2016-07-12 09:18
Peer-Review Started	2016-07-13 17:14
To Make the First Decision	2016-10-10 09:46
Return for Revision	2016-10-17 19:33
Revised	2016-10-28 06:45
Second Decision	2016-12-26 11:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 14:53
Articles in Press	2017-01-14 14:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-07 17:11
Publish the Manuscript Online	2017-03-13 13:20

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver
Manuscript Source	Invited Manuscript
All Author List	Ana Claudia Reis Schneider, Cleandra Gregório, Carolina Uribe-Cruz, Ranieli Guizzo, Tais Malysz, Maria Cristina Faccioni-Heuser, Larisse Longo and Themis Reverbel da Silveira
Funding Agency and Grant Number
Corresponding Author	Ana Claudia Reis Schneider, PhD, Laboratório Experimental de Hepatologia e Gastroenterologia, Hospital de Clínicas de Porto Alegre, 2350/sala 12214, Porto Alegre, 90035-903 RS, Brazil. schneiderac@gmail.com
Key Words	Ethanol; Hepatic steatosis; Inflammation; Zebrafish; Alcoholic fatty liver
Core Tip	Excessive alcohol consumption remains one of the most important causes of liver disease worldwide. Alcoholic steatosis results from the deposition of fat in liver cells and is the earliest stage of alcohol-related liver disease. Usually inflammation is associated with steatohepatitis, however our results demonstrate that chronic ethanol exposure increased the expression of the inflammatory gene interleukin-1b. Paradoxically the expression of adiponectin receptor-2 and sirtuin-1 also increased for attenuating the liver injury. Ultrastructural abnormalities were observed showing early alterations in liver cells. Knowledge of alcohol injury mechanisms will contribute to the development of novel therapies in the treatment of alcoholic liver disease.
Publish Date	2017-03-13 13:20
Citation	Schneider ACR, Gregório C, Uribe-Cruz C, Guizzo R, Malysz T, Faccioni-Heuser MC, Longo L, da Silveira TR. Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver. World J Hepatol 2017; 9(8): 418-426
URL	http://www.wjgnet.com/1948-5182/full/v9/i8/418.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i8.418

Full Article (PDF)	WJH-9-418.pdf
Full Article (Word)	WJH-9-418.doc
Manuscript File	28711-Review.docx
Answering Reviewers	28711-Answering reviewers.pdf
Audio Core Tip	28711-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28711-Conflict-of-interest statement.pdf
Copyright License Agreement	28711-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	28711-Institutional animal care and use committee statement.pdf
Peer-review Report	28711-Peer-review(s).pdf
Scientific Misconduct Check	28711-Scientific misconduct check.pdf
Scientific Editor Work List	28711-Scientific editor work list.pdf