Publication Name	World Journal of Gastroenterology
Manuscript ID	2874
Country	China

Received	2013-03-21 10:21
Peer-Review Started	2013-03-21 12:05
To Make the First Decision	2013-04-03 09:11
Return for Revision	2013-04-16 16:54
Revised	2013-05-06 10:17
Second Decision	2013-06-03 16:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-04 13:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-03 11:46
Publish the Manuscript Online	2013-07-13 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation
Manuscript Source	Invited Manuscript
All Author List	Lin-Hai Yan, Xiao-Tong Wang, Jie Yang, Chao Lian, Fan-Biao Kong, Wei-Yuan Wei, Wen Luo, Qiang Xiao and Yu-Bo Xie
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81060201 Natural Science Foundation of Guangxi 2011GXNSFA018273 Natural Science Foundation of Guangxi 2013GXNSFAA019163 Key Health Science Foundation of Guangxi 1298003-2-6
Corresponding Author	Qiang Xiao, Professor, Department of Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Key Words	Homeobox gene CDX2; RNA interference; Gastric cancer; Drug resistance; Murine model
Core Tip	Modulator of multidrug resistance (MDR) gene is a direct transcriptional target of CDX2. However, we still speculate whether CDX2 affects MDR through other ways. Our results showed that downregulation of CDX2 significantly promoted sensitivity of SGC7901/DDP cells to anticancer drugs, and increased the percentage of apoptotic cells. Downregulation of CDX2 potentiated G1 phase arrest of the cell cycle. Furthermore, it significantly increased intracellular accumulation of doxorubicin. We conclude that downregulation of CDX2 can efficiently reverse MDR via inhibition of apoptosis/cell-cycle-related gene expression (c-Myc, survivin and cyclin D1).
Publish Date	2013-07-13 17:01
Citation	Yan LH, Wang XT, Yang J, Lian C, Kong FB, Wei WY, Luo W, Xiao Q, Xie YB. Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation. World J Gastroenterol 2013; 19(26): 4155-4165
URL	http://www.wjgnet.com/1007-9327/full/v19/i26/4155.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i26.4155

Full Article (PDF)	WJG-19-4155.pdf
Manuscript File	wjg-2013-2874-Review.doc
Answering Reviewers	2874-Answering reviewers.pdf
Copyright License Agreement	2874-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2874-Language certificate.pdf
Peer-review Report	2874-Peer reviews.pdf
Scientific Editor Work List	2874-Scientific editor work list.doc