Publication Name	World Journal of Gastroenterology
Manuscript ID	28753
Country	China

Received	2016-07-13 16:35
Peer-Review Started	2016-07-17 18:44
To Make the First Decision	2016-08-19 10:54
Return for Revision	2016-08-23 11:02
Revised	2016-09-05 09:47
Second Decision	2016-09-09 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-09-14 13:09
Articles in Press	2016-09-14 13:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-11-09 12:54
Typeset the Manuscript	2016-12-20 12:35
Publish the Manuscript Online	2017-01-05 11:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Role of mast cell-miR-490-5p in irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Xia Ren, Fa-Can Zhang, He-Sheng Luo, Guo Zhang and Lie-Xin Liang
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81160053
Corresponding Author	He-Sheng Luo, MD, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. xhnk@163.com
Key Words	miR-490-5p; Mast cell tryptase; PAR-2; Irritable bowel syndrome
Core Tip	Mast cells and mast cell degranulation play important roles in the pathophysiology of irritable bowel syndrome. miRNA is a class of important endogenous single-stranded non-coding RNA, and plays an essential regulatory role in complex biological systems without protein translation. In the present study, we aimed to determine the role of miR-490-5p in regulating mast cell proliferation and apoptosis, the expression of mast cell tryptase and PAR-2, and thus predict the role of miR-490-5p in the pathogenesis of irritable bowel syndrome.
Publish Date	2017-01-05 11:10
Citation	Ren HX, Zhang FC, Luo HS, Zhang G, Liang LX. Role of mast cell-miR-490-5p in irritable bowel syndrome. World J Gastroenterol 2017; 23(1): 93-102
URL	http://www.wjgnet.com/1007-9327/full/v23/i1/93.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i1.93

Full Article (PDF)	WJG-23-93.pdf
Full Article (Word)	WJG-23-93.doc
Manuscript File	28753-Review.docx
Answering Reviewers	28753-Answering reviewers.pdf
Audio Core Tip	28753-Audio core tip.mp3
Biostatistics Review Certificate	28753-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28753-Conflict-of-interest statement.pdf
Copyright License Agreement	28753-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28753-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20160713153610.docx
Institutional Review Board Approval Form or Document	28753-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28753-Language certificate.pdf
Peer-review Report	28753-Peer-review(s).pdf
Scientific Misconduct Check	28753-Scientific misconduct check.pdf
Scientific Editor Work List	28753-Scientific editor work list.pdf