Publication Name	World Journal of Gastroenterology
Manuscript ID	28755
Country	Japan

Received	2016-07-13 17:08
Peer-Review Started	2016-07-16 20:00
To Make the First Decision	2016-08-19 10:54
Return for Revision	2016-08-23 11:03
Revised	2016-09-08 15:29
Second Decision	2016-09-21 15:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-09-28 18:03
Articles in Press	2016-09-28 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-19 11:07
Publish the Manuscript Online	2016-10-26 17:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies
Manuscript Source	Invited Manuscript
All Author List	Hidenori Ojima, Seri Yamagishi, Kazuaki Shimada and Tatsuhiro Shibata
Funding Agency and Grant Number
Corresponding Author	Hidenori Ojima, MD, PhD, Division of Molecular Pathology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. hojima@a3.keio.jp
Key Words	Biliary tract carcinoma; Cell line; Xenograft model; Preclinical study
Core Tip	Although the need for developing novel therapeutic strategies for biliary tract carcinoma (BTC) is increasing, there are only few xenograft models and cell lines available for in vivo and in vitro studies, respectively. To conduct appropriate preclinical studies, we established 28 xenograft models and 13 new BTC cell lines using several surgical BTC specimens and immunodeficient mice. Using the aforementioned cell lines and xenograft models and a clinical pathological database of patients undergoing BTC resection, we can establish appropriate parameters for drug efficacy studies to explore new biomarkers for practical applications in the future studies.
Publish Date	2016-10-26 17:34
Citation	Ojima H, Yamagishi S, Shimada K, Shibata T. Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies. World J Gastroenterol 2016; 22(40): 9035-9038
URL	http://www.wjgnet.com/1007-9327/full/v22/i40/9035.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i40.9035

Full Article (PDF)	WJG-22-9035.pdf
Full Article (Word)	WJG-22-9035.doc
Manuscript File	28755-Review.docx
Answering Reviewers	28755-Answering reivewers.pdf
Audio Core Tip	28755-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28755-Conflict-of-interest statement.pdf
Copyright License Agreement	28755-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20160713155117.pdf
Non-Native Speakers of English Editing Certificate	28755-Language certificate.pdf
Peer-review Report	28755-Peer-review(s).pdf
Scientific Misconduct Check	28755-Scientific misconduct check.pdf
Scientific Editor Work List	28755-Scientific editor work list.pdf