Publication Name	World Journal of Gastroenterology
Manuscript ID	28897
Country	Japan

Received	2016-07-20 14:45
Peer-Review Started	2016-07-22 10:21
To Make the First Decision	2016-07-29 15:15
Return for Revision	2016-07-29 19:16
Revised	2016-08-11 02:33
Second Decision	2016-08-17 08:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-23 17:35
Articles in Press	2016-08-23 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-04 14:58
Publish the Manuscript Online	2016-11-12 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura and Hirohiko Sakamoto
Funding Agency and Grant Number
Corresponding Author	Michitoshi Takano, MD, Division of gastroenterological surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan. michitaka1983@gmail.com
Key Words	Hepatocellular carcinoma; Sorafenib; Complete response; Portal vein tumor thrombosis; Transcatheter arterial chemoembolization
Core Tip	Patients with advanced hepatocellular carcinoma (HCC) showing portal vein tumor thrombosis (PVTT) have an extremely poor prognosis. The only proposed treatment option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. Here we report the first case of a patient with an initially unresectable advanced HCC and PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization (TACE) showing complete histological response. The combination of sorafenib and TACE may be an effective treatment for HCC patients with PVTT.
Publish Date	2016-11-12 13:34
Citation	Takano M, Kokudo T, Miyazaki Y, Kageyama Y, Takahashi A, Amikura K, Sakamoto H. Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma. World J Gastroenterol 2016; 22(42): 9445-9450
URL	http://www.wjgnet.com/1007-9327/full/v22/i42/9445.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i42.9445

Full Article (PDF)	WJG-22-9445.pdf
Full Article (Word)	WJG-22-9445.doc
Manuscript File	28897-Review.docx
Answering Reviewers	28897-Answering reviewers.pdf
Audio Core Tip	28897-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28897-Conflict-of-interest statement.pdf
Copyright License Agreement	28897-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	28897-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28897-Language certificate.pdf
Peer-review Report	28897-Peer-review(s).pdf
Scientific Misconduct Check	28897-Scientific misconduct check.pdf
Scientific Editor Work List	28897-Scientific editor work list.pdf