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Articles Published Processes
11/3/2016 3:50:00 PM | Browse: 1090 | Download: 1968
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Received |
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2016-07-20 17:25 |
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Peer-Review Started |
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2016-07-21 17:07 |
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To Make the First Decision |
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2016-08-04 16:30 |
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Return for Revision |
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2016-08-05 12:25 |
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Revised |
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2016-08-10 10:09 |
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Second Decision |
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2016-09-12 10:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-09-22 14:20 |
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Articles in Press |
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2016-09-22 14:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-31 16:09 |
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Publish the Manuscript Online |
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2016-11-03 15:47 |
| ISSN |
2218-6204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Basic Study |
| Article Title |
P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Megan Faulks, Tracey A Kuit, Reece A Sophocleous, Belinda L Curtis, Stephen J Curtis, Lisa M Jurak and Ronald Sluyter |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Centre for Medical and Molecular Bioscience (University of Wollongong) |
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| American Kennel Club Canine Health Foundation |
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| Corresponding Author |
Ronald Sluyter, PhD, Associate Professor, School of Biological Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia. rsluyter@uow.edu.au |
| Key Words |
Adenosine triphosphate; Dog; P2X1 receptor; P2X7 receptor; Phospholipid; Purinergic receptor; Red blood cells |
| Core Tip |
Phosphatidylserine (PS) exposure in erythrocytes has potential roles in erythrocyte clearance and thrombus formation. Activation of the ATP-gated P2X7 receptor channel induces PS exposure in human erythrocytes, but whether this process occurs in erythrocytes from other mammals remained hitherto unknown. The current study shows that extracellular ATP causes PS exposure in dog erythrocytes from 13 pedigrees and seven crossbreeds. Notably, the current study shows that this process is mediated by P2X7 activation. These results suggest that P2X7-mediated PS exposure on erythrocytes may have important roles in red blood cell biology in dogs. |
| Publish Date |
2016-11-03 15:47 |
| Citation |
Faulks M, Kuit TA, Sophocleous RA, Curtis BL, Curtis SJ, Jurak LM, Sluyter R. P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes. World J Hematol 2016; 5(4): 88-93 |
| URL |
http://www.wjgnet.com/2218-6204/full/v5/i4/88.htm |
| DOI |
http://dx.doi.org/10.5315/wjh.v5.i4.88 |
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