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1/5/2017 11:10:00 AM | Browse: 873 | Download: 1414
Publication Name World Journal of Gastroenterology
Manuscript ID 28906
Country/Territory Poland
Received
2016-07-21 09:19
Peer-Review Started
2016-07-22 18:58
To Make the First Decision
2016-10-20 13:13
Return for Revision
2016-10-20 16:25
Revised
2016-11-02 02:18
Second Decision
2016-11-11 16:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-11-28 18:03
Articles in Press
2016-11-28 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-15 15:12
Publish the Manuscript Online
2017-01-05 11:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Trefoil factor-3 is not a useful marker of mucosal healing in Crohn's disease treated with anti-TNF-α antibodies
Manuscript Source Invited Manuscript
All Author List Piotr Eder, Kamila Stawczyk-Eder, Katarzyna Korybalska, Natasza Czepulis, Joanna Luczak, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke and Janusz Witowski
Funding Agency and Grant Number
Funding Agency Grant Number
Poznan University of Medical Sciences A helping hand (2014)
Corresponding Author Piotr Eder, MD, PhD, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Heliodor Swiecicki Hospital, Przybyszewskiego Street 49, 60-355 Poznan, Poland. piotr.eder@op.pl
Key Words Adalimumab; Crohn’s disease; Infliximab; Mucosal healing; Trefoil factors
Core Tip Mucosal healing (MH) is viewed as the holy grail of the efficacy of anti-tumor necrosis factor-α (anti-TNF-α) therapy for Crohn’s disease (CD), however performance of repeated colonoscopies is questionable for economical and safety reasons. We aimed to assess, whether serum trefoil factor-3 (TFF-3), a parameter engaged in maintaining mucosal integrity, could be useful in the assessment of MH. We found no correlation between TFF-3 and CD endoscopic activity and fecal calprotectin. Changes in TFF-3 did not reflect the degree to which MH was achieved. Thus, TFF-3 does not seem to be a reliable surrogate marker for MH in CD patients undergoing anti-TNF-α therapy.
Publish Date 2017-01-05 11:10
Citation Eder P, Stawczyk-Eder K, Korybalska K, Czepulis N, Luczak J, Lykowska-Szuber L, Krela-Kazmierczak I, Linke K, Witowski J. Trefoil factor-3 is not a useful marker of mucosal healing in Crohn’s disease treated with anti-TNF-α antibodies. World J Gastroenterol 2017; 23(1): 135-140
URL http://www.wjgnet.com/1007-9327/full/v23/i1/135.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i1.135
Full Article (PDF) WJG-23-135.pdf
Full Article (Word) WJG-23-135.doc
Manuscript File 28906-Review.doc
Answering Reviewers 28906-Answering reviewers.pdf
Audio Core Tip 28906-Audio core tip.mp3
Biostatistics Review Certificate 28906-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28906-Conflict of interest statement-Revised manuscript.pdf
Copyright License Agreement 28906-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28906-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160720150956.pdf
Institutional Review Board Approval Form or Document 28906-Intitutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28906-Language certificate.pdf
Peer-review Report 28906-Peer-review(s).pdf
Scientific Misconduct Check 28906-Scientific misconduct check.pdf
Scientific Editor Work List 28906-Scientific editor work list.pdf