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Articles Published Processes
1/5/2017 11:10:00 AM | Browse: 1181 | Download: 2398
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Received |
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2016-07-21 09:19 |
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Peer-Review Started |
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2016-07-22 18:58 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-10-20 16:25 |
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Revised |
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2016-11-02 02:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-11-11 16:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-11-28 18:03 |
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Articles in Press |
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2016-11-28 18:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-15 15:12 |
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Publish the Manuscript Online |
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2017-01-05 11:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Trefoil factor-3 is not a useful marker of mucosal healing in Crohn's disease treated with anti-TNF-α antibodies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Piotr Eder, Kamila Stawczyk-Eder, Katarzyna Korybalska, Natasza Czepulis, Joanna Luczak, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke and Janusz Witowski |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Poznan University of Medical Sciences |
A helping hand (2014) |
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| Corresponding Author |
Piotr Eder, MD, PhD, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Heliodor Swiecicki Hospital, Przybyszewskiego Street 49, 60-355 Poznan,
Poland. piotr.eder@op.pl
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| Key Words |
Adalimumab; Crohn’s disease; Infliximab; Mucosal healing; Trefoil factors |
| Core Tip |
Mucosal healing (MH) is viewed as the holy grail of the efficacy of anti-tumor necrosis factor-α (anti-TNF-α) therapy for Crohn’s disease (CD), however performance of repeated colonoscopies is questionable for economical and safety reasons. We aimed to assess, whether serum trefoil factor-3 (TFF-3), a parameter engaged in maintaining mucosal integrity, could be useful in the assessment of MH. We found no correlation between TFF-3 and CD endoscopic activity and fecal calprotectin. Changes in TFF-3 did not reflect the degree to which MH was achieved. Thus, TFF-3 does not seem to be a reliable surrogate marker for MH in CD patients undergoing anti-TNF-α therapy.
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| Publish Date |
2017-01-05 11:10 |
| Citation |
Eder P, Stawczyk-Eder K, Korybalska K, Czepulis N, Luczak J, Lykowska-Szuber L, Krela-Kazmierczak I, Linke K, Witowski J. Trefoil factor-3 is not a useful marker of mucosal healing in Crohn’s disease treated with anti-TNF-α antibodies. World J Gastroenterol 2017; 23(1): 135-140 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i1/135.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i1.135 |
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