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2/12/2017 5:24:00 PM | Browse: 351 | Download: 420
Publication Name World Journal of Gastroenterology
Manuscript ID 28907
Country/Territory China
Received
2016-08-18 11:08
Peer-Review Started
2016-08-19 17:11
To Make the First Decision
2016-09-06 16:31
Return for Revision
2016-09-07 11:54
Revised
2016-09-26 17:53
Second Decision
2016-10-25 20:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-31 15:02
Articles in Press
2016-10-31 15:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-11-17 06:37
Typeset the Manuscript
2017-02-03 19:15
Publish the Manuscript Online
2017-02-12 17:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis
Manuscript Source Unsolicited Manuscript
All Author List Hong-Wei Zhao, Yue-Hong Yue, Hua Han, Xiu-Li Chen, Yong-Gang Lu, Ji-Min Zheng, Hong-Tao Hou, Xiao-Meng Lang, Li-Li He, Qi-Lu Hu and Zi-Qian Dun
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research Foundation of Health Department of Hebei Province 20160483
Corresponding author Hong-Wei Zhao, MD, Department of Gastroenterology, Hebei General Hospital, No.348 Hepingxi Road, Shijiazhuang 050051, Hebei Province, China. hongweizhao788@163.com
Keywords Dextran sulfate sodium-induced acute colitis; Mucosal injury; Epithelial barrier disruption; Tight junction; Poly I:C
Core Tip Poly I:C, a toll-like receptor 3 agonist, has been previously reported to protect against acute colitis. The potential effects of poly I:C on mucosal injury and epithelial barrier disruption were investigated in mouse models of dextran sulfate sodium (DSS)-induced acute colitis. Poly I:C administration dramatically protected against DSS-induced colitis, with ameliorated ultrastructural changes of colon epithelium, intestinal permeability and tight junction protein expressions. Poly I:C may protect against DSS-induced colitis through maintaining integrity of the epithelial barrier and regulating innate immune responses.
Publish Date 2017-02-12 17:23
Citation Zhao HW, Yue YH, Han H, Chen XL, Lu YG, Zheng JM, Hou HT, Lang XM, He LL, Hu QL, Dun ZQ. Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis. World J Gastroenterol 2017; 23(6): 999-1009
Url http://www.wjgnet.com/1007-9327/full/v23/i6/999.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i6.999
Full Article (PDF) WJG-23-999.pdf
Full Article (Word) WJG-23-999.doc
Manuscript File 28907-Review.docx
Answering Reviewers 28907-Answering reviewers.pdf
Audio Core Tip 28907-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 28907-Conflict-of-interest statement.pdf
Copyright License Agreement 28907-Copyright assignment.pdf
Data Sharing Statement 28907-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28907-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 28907-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 28907-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28907-Language certificate.pdf
Scientific Research Process 28907-Scientific research process.pdf
Peer-review Report 28907-Peer-review(s).pdf
Scientific Misconduct Check 28907-Scientific misconduct check.pdf
Scientific Editor Work List 28907-Scientific editor work list.pdf