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Articles Published Processes
2/12/2017 5:24:00 PM | Browse: 987 | Download: 2052
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Received |
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2016-08-18 11:08 |
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Peer-Review Started |
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2016-08-19 17:11 |
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To Make the First Decision |
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2016-09-06 16:31 |
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Return for Revision |
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2016-09-07 11:54 |
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Revised |
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2016-09-26 17:53 |
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Second Decision |
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2016-10-25 20:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-31 15:02 |
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Articles in Press |
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2016-10-31 15:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-11-17 06:37 |
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Typeset the Manuscript |
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2017-02-03 19:15 |
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Publish the Manuscript Online |
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2017-02-12 17:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Wei Zhao, Yue-Hong Yue, Hua Han, Xiu-Li Chen, Yong-Gang Lu, Ji-Min Zheng, Hong-Tao Hou, Xiao-Meng Lang, Li-Li He, Qi-Lu Hu and Zi-Qian Dun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Foundation of Health Department of Hebei Province |
20160483 |
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| Corresponding Author |
Hong-Wei Zhao, MD, Department of Gastroenterology, Hebei General Hospital, No.348 Hepingxi Road, Shijiazhuang 050051, Hebei Province, China. hongweizhao788@163.com
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| Key Words |
Dextran sulfate sodium-induced acute colitis; Mucosal injury; Epithelial barrier disruption; Tight junction; Poly I:C |
| Core Tip |
Poly I:C, a toll-like receptor 3 agonist, has been previously reported to protect against acute colitis. The potential effects of poly I:C on mucosal injury and epithelial barrier disruption were investigated in mouse models of dextran sulfate sodium (DSS)-induced acute colitis. Poly I:C administration dramatically protected against DSS-induced colitis, with ameliorated ultrastructural changes of colon epithelium, intestinal permeability and tight junction protein expressions. Poly I:C may protect against DSS-induced colitis through maintaining integrity of the epithelial barrier and regulating innate immune responses. |
| Publish Date |
2017-02-12 17:23 |
| Citation |
Zhao HW, Yue YH, Han H, Chen XL, Lu YG, Zheng JM, Hou HT, Lang XM, He LL, Hu QL, Dun ZQ. Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis. World J Gastroenterol 2017; 23(6): 999-1009 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i6/999.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i6.999 |
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