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Articles Published Processes
12/6/2016 5:24:00 PM | Browse: 1328 | Download: 1591
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Received |
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2016-07-21 14:05 |
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Peer-Review Started |
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2016-07-25 08:36 |
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To Make the First Decision |
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2016-09-28 09:24 |
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Return for Revision |
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2016-09-28 15:12 |
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Revised |
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Second Decision |
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2016-11-01 08:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-11-13 15:19 |
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Articles in Press |
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2016-11-13 15:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-22 10:36 |
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Publish the Manuscript Online |
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2016-12-06 17:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stefano Crippa, Stefano Partelli, Giulio Belfiori, Marco Palucci, Francesca Muffatti, Olga Adamenko, Luca Cardinali, Claudio Doglioni, Giuseppe Zamboni and Massimo Falconi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Stefano Crippa, MD, PhD, Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy. crippa1.stefano@hsr.it
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| Key Words |
Pancreatic neuroendocrine tumors; Surgery; Neuroendocrine carcinomas; Chemotherapy; Prognosis; Metastases; Morphology; Proliferation |
| Core Tip |
In this study, we reviewed the available literature for neuroendocrine carcinomas of the pancreas with a special focus on the differences between morphological poorly-differentiated and well-differentiated tumors. Although the quality of current evidence is suboptimal because of the retrospective design of the available studies, morphological well-differentiated tumors are associated with lower ki67 proliferative index, are less responsive to standard platinum-based chemotherapy and are associated with improved survival. The current category of neuroendocrine carcinomas should be revised taking into account these differences and new diagnostic criteria should be considered in order to clearly define poorly- and well-differentiated tumors.
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| Publish Date |
2016-12-06 17:24 |
| Citation |
Crippa S, Partelli S, Belfiori G, Palucci M, Muffatti F, Adamenko O, Cardinali L, Doglioni C, Zamboni G, Falconi M. Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology. World J Gastroenterol 2016; 22(45): 9944-9953 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i45/9944.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i45.9944 |
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