Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	28934
Country	Netherlands

Received	2016-07-22 09:26
Peer-Review Started	2016-07-26 08:47
To Make the First Decision	2016-09-05 09:17
Return for Revision	2016-09-06 08:17
Revised	2016-09-12 21:48
Second Decision	2016-09-20 15:54
Accepted by Journal Editor-in-Chief	2016-09-20 22:49
Accepted by Executive Editor-in-Chief	2016-10-09 10:40
Articles in Press	2016-10-09 10:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-24 14:27
Publish the Manuscript Online	2016-10-31 09:01

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	How I treat my inflammatory bowel disease-patients with thiopurines?
Manuscript Source	Invited Manuscript
All Author List	Berrie Meijer, Chris JJ Mulder, Adriaan A van Bodegraven and Nanne KH de Boer
Funding Agency and Grant Number
Corresponding Author	Nanne KH de Boer, MD, PhD, Department of Gastroenterology and Hepatology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. khn.deboer@vumc.nl
Key Words	Thiopurines; Azathioprine; Mercaptopurine; Thioguanine; Inflammatory bowel disease; Therapeutic drug monitoring; Pregnancy; Metabolites
Core Tip	Conventional thiopurine therapy with azathioprine and mercaptopurine in inflammatory bowel disease is associated with several adverse events causing cessation of therapy in up to half of the patients. On the contrary, thiopurine therapy is often unnecessarily discontinued. In this practical review, we provide information on how thiopurine therapy is initiated and maintained using periodical laboratory tests and the application of various treatment strategies (including the administration of a third thiopurine; thioguanine), based on the experience in the two expert thiopurine centers in The Netherlands.
Publish Date	2016-10-31 09:01
Citation	Meijer B, Mulder CJJ, van Bodegraven AA, de Boer NKH. How I treat my inflammatory bowel disease-patients with thiopurines? World J Gastrointest Pharmacol Ther 2016; 7(4): 524-530
URL	http://www.wjgnet.com/2150-5349/full/v7/i4/524.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i4.524

Full Article (PDF)	WJGPT-7-524.pdf
Full Article (Word)	WJGPT-7-524.doc
Manuscript File	28934-Review.docx
Answering Reviewers	28934-Answering reviewers.pdf
Audio Core Tip	28934-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	28934-Conflict-of-interest statement.pdf
Copyright License Agreement	28934-Copyright assignment.pdf
Peer-review Report	28934-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28934-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28934-Scientific misconduct check.pdf
Scientific Editor Work List	28934-Scientific editor work list.pdf