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5/12/2017 2:02:36 PM | Browse: 951 | Download: 1673
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 29051
Country/Territory United Kingdom
Received
2016-07-27 18:29
Peer-Review Started
2016-07-30 19:48
To Make the First Decision
2016-09-29 13:55
Return for Revision
2016-09-30 16:13
Revised
2016-12-20 02:37
Second Decision
2017-03-15 17:25
Accepted by Journal Editor-in-Chief
2017-03-15 17:44
Accepted by Company Editor-in-Chief
2017-03-24 10:18
Articles in Press
2017-03-24 10:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-10 13:37
Publish the Manuscript Online
2017-05-12 14:02
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype
Manuscript Source Invited Manuscript
All Author List Jeremy Stuart Williamson, Huw Geraint Jones, Namor Williams, Anthony Paul Griffiths, Gareth Jenkins, John Beynon and Dean Anthony Harris
Funding Agency and Grant Number
Corresponding Author Dr. Jeremy Stuart Williamson, Depart­ment of General and Colorectal Surgery, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, United Kingdom. dean.a.harris@wales.nhs.uk
Key Words Rectal cancer; CpG islands; methylation
Core Tip There is wide and unpredictable response of rectal cancer to neoadjuvant therapy which carries significant side effects and relies on limited pre-treat­ment risk stratification. Methylation specific PCR was used to determine CpG island Methylator phenotype (CIMP) status in 160 rectal cancers and compared with response to therapy, clinical and pathological outcomes. CIMP status was not directly related to tumour regression but was related to extramural vascular invasion which confers an adverse survival risk.
Publish Date 2017-05-12 14:02
Citation Williamson JS, Jones HG, Williams N, Griffiths AP, Jenkins G, Beynon J, Harris DA. Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype. World J Gastrointest Oncol 2017; 9(5): 209-217
URL http://www.wjgnet.com/1948-5204/full/v9/i5/209.htm
DOI http://dx.doi.org/10.4251/wjgo.v9.i5.209
Full Article (PDF) WJGO-9-209.pdf
Full Article (Word) WJGO-9-209.doc
Manuscript File 29051-Review.docx
Answering Reviewers 29051-Answering reviewers.pdf
Audio Core Tip 29051-Audio core tip.m4a
Biostatistics Review Certificate 29051-Biostatistics statement.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20160727163358.docx
Conflict-of-Interest Disclosure Form 29051-Conflict-of-interest statement.pdf
Copyright License Agreement 29051-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160727163404.docx
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20160727163411.docx
Institutional Review Board Approval Form or Document 29051-Institutional review board statement.pdf
Peer-review Report 29051-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 29051-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 29051-Scientific misconduct check.pdf
Scientific Editor Work List 29051-Scientific editor work list.pdf