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Articles Published Processes
5/12/2017 2:02:36 PM | Browse: 1066 | Download: 2087
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Received |
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2016-07-27 18:29 |
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Peer-Review Started |
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2016-07-30 19:48 |
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To Make the First Decision |
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2016-09-29 13:55 |
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Return for Revision |
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2016-09-30 16:13 |
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Revised |
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2016-12-20 02:37 |
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Second Decision |
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2017-03-15 17:25 |
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Accepted by Journal Editor-in-Chief |
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2017-03-15 17:44 |
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Accepted by Executive Editor-in-Chief |
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2017-03-24 10:18 |
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Articles in Press |
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2017-03-24 10:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-10 13:37 |
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Publish the Manuscript Online |
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2017-05-12 14:02 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jeremy Stuart Williamson, Huw Geraint Jones, Namor Williams, Anthony Paul Griffiths, Gareth Jenkins, John Beynon and Dean Anthony Harris |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Jeremy Stuart Williamson, Department of General and Colorectal Surgery, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, United Kingdom. dean.a.harris@wales.nhs.uk |
| Key Words |
Rectal cancer; CpG islands; methylation |
| Core Tip |
There is wide and unpredictable response of rectal cancer to neoadjuvant therapy which carries significant side effects and relies on limited pre-treatment risk stratification. Methylation specific PCR was used to determine CpG island Methylator phenotype (CIMP) status in 160 rectal cancers and compared with response to therapy, clinical and pathological outcomes. CIMP status was not directly related to tumour regression but was related to extramural vascular invasion which confers an adverse survival risk. |
| Publish Date |
2017-05-12 14:02 |
| Citation |
Williamson JS, Jones HG, Williams N, Griffiths AP, Jenkins G, Beynon J, Harris DA. Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype. World J Gastrointest Oncol 2017; 9(5): 209-217 |
| URL |
http://www.wjgnet.com/1948-5204/full/v9/i5/209.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v9.i5.209 |
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