Publication Name	World Journal of Hepatology
Manuscript ID	29058
Country	United Kingdom

Received	2016-07-28 09:59
Peer-Review Started	2016-07-29 15:55
To Make the First Decision	2016-09-27 17:09
Return for Revision	2016-09-28 11:55
Revised	2016-11-12 07:47
Second Decision	2017-01-04 15:54
Accepted by Journal Editor-in-Chief	2017-01-04 16:02
Accepted by Company Editor-in-Chief	2017-01-14 14:24
Articles in Press	2017-01-14 14:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-22 17:16
Publish the Manuscript Online	2017-02-27 08:50

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Anesthesiology
Manuscript Type	Observational Study
Article Title	Thrombocytopenia in cirrhosis: Impact of fibrinogen on bleeding risk
Manuscript Source	Invited Manuscript
All Author List	Sonali V Thakrar and Susan V Mallett
Funding Agency and Grant Number
Corresponding Author	Sonali V Thakrar, MBBS, BSc (Hons), MRCP, FRCA, Clinical Research Fellow, Royal Free Perio­perative Research Group, Department of Anaesthesia, Royal Free London, Pond Street, London NW3 2QG, United Kingdom. s.thakrar1@nhs.net
Key Words	Thrombocytopenia; Cirrhosis; Haemostasis; Fibrinogen; Liver transplantation
Core Tip	Current literature describing bleeding risk in thrombocytopenia and cirrhosis does not take into account the impact of fibrinogen. The minimal platelet count to form a clot with normal strength is unknown, and would be influenced by fibrinogen. Viscoelastic testing, particularly maximum amplitude (MA, thromboelastography) or maxi-mum-clot-firmness (MCF, thromboelastometry), reflects platelet-fibrinogen interaction and allows assessment of clot strength. Low platelet count and low fibrinogen levels lead to low MA/MCF and correlate strongly with increased bleeding tendency. Assessment of platelet count alone does not accurately predict bleeding, but is useful in conjunction with other indices such as clauss fibrinogen and MA/MCF.
Publish Date	2017-02-27 08:50
Citation	Thakrar SV, Mallett SV. Thrombocytopenia in cirrhosis: Impact of fibrinogen on bleeding risk. World J Hepatol 2017; 9(6): 318-325
URL	http://www.wjgnet.com/1948-5182/full/v9/i6/318.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i6.318

Full Article (PDF)	WJH-9-318.pdf
Full Article (Word)	WJH-9-318.doc
Manuscript File	29058-Review.docx
Answering Reviewers	29058-Answering reviewers.pdf
Audio Core Tip	29058-Audio core tip.m4a
Biostatistics Review Certificate	Biostatistics_Statement_20160727183510.pdf
Conflict-of-Interest Disclosure Form	29058-Conflict-of-interest statement.pdf
Copyright License Agreement	29058-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160727183719.pdf
Institutional Review Board Approval Form or Document	29058-Institutional review board statement.pdf
Peer-review Report	29058-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29058-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29058-Scientific misconduct check.pdf
Scientific Editor Work List	29058-Scientific editor work list.pdf