Publication Name	World Journal of Medical Genetics
Manuscript ID	2906
Country	Japan

Received	2013-03-23 23:30
Peer-Review Started	2013-03-24 19:01
To Make the First Decision	2013-04-16 08:59
Return for Revision	2013-04-17 16:23
Revised	2013-05-14 14:05
Second Decision	2013-06-03 16:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-04 09:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-06-06 13:13
Typeset the Manuscript	2013-06-09 19:30
Publish the Manuscript Online	2013-07-19 16:12

ISSN	2220-3184 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Field of Vision
Article Title	Fiber-fluorescence in situ hybridization analyses as a diagnostic application for orientation of microduplications
Manuscript Source	Invited Manuscript
All Author List	Toshiyuki Yamamoto, Shino Shimada and Keiko Shimojima
Funding Agency and Grant Number
Corresponding Author	Toshiyuki Yamamoto, MD, PhD, Tokyo Women’s Medical University Institute for Integrated Medical Sciences, Kawada-cho 8-1, Shinjuku-ward, Tokyo 162-8666, Japan. yamamoto.toshiyuki@twmu.ac.jp
Key Words	Chromosomal microarray testing; Copy number variation; Fiber-fluorescence in situ hybridization; Microduplication; Tandem orientation
Core Tip	Fiber-fluorescence in situ hybridization analysis has the potential to reveal the orientation of duplicated and triplicated segments of chromosomes. Previously, we reported that interstitial duplications were aligned in tandem configurations, supporting the hypothesized mechanism of non-allelic homologous recombination; however, there were rare cases of inverted duplications. Further analysis is therefore required to fully elucidate the basic mechanisms underlying such duplications/triplications.
Publish Date	2013-07-19 16:12
Citation	Yamamoto T, Shimada S, Shimojima K. Fiber-fluorescence in situ hybridization analyses as a diagnostic application for orientation of microduplications. World J Med Genet 2013; 3(2): 5-8
URL	http://www.wjgnet.com/2220-3184/full/v3/i2/5.htm
DOI	http://dx.doi.org/10.5496/wjmg.v3.i2.5

Full Article (PDF)	WJMG-3-5.pdf
Manuscript File	2906-Review.doc
Answering Reviewers	2906-Answering reviewers.pdf
Copyright License Agreement	2906-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	2906-Language certificate.pdf
Peer-review Report	2906-Peer reviews.pdf
Scientific Editor Work List	2906-Scientific editor work list.doc