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11/6/2016 3:43:00 PM | Browse: 973 | Download: 1622
Publication Name World Journal of Gastroenterology
Manuscript ID 29084
Country Ireland
Received
2016-08-10 11:25
Peer-Review Started
2016-08-11 10:07
To Make the First Decision
2016-09-12 17:01
Return for Revision
2016-09-14 16:11
Revised
2016-09-27 06:42
Second Decision
2016-10-10 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-19 17:17
Articles in Press
2016-10-19 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-04 08:57
Publish the Manuscript Online
2016-11-06 15:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples
Manuscript Source Invited Manuscript
All Author List Denise E Brennan, Joseph Omorogbe, Mary Hussey, Donal Tighe, Grainne Holleran, Colm O’Morain, Sinéad M Smith and Deirdre McNamara
Funding Agency and Grant Number
Corresponding Author Dr. Sinéad M Smith, PhD, Assistant Professor, Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Tallaght, Dublin 2, Ireland. smithsi@tcd.ie
Key Words Helicobacter pylori; Antibiotic resistance; Clarithromycin; Fluoroquinolone; Molecular methods
Core Tip The successful detection of clarithromycin and/or fluoroquinolone resistant Helicobacter pylori (H. pylori) infections by non-invasive methods would enable a widespread assessment of resistance rates. Here we evaluate the GenoType HelicoDR assay for the detection of clarithromycin and fluoroquinolone resistance using DNA isolated from stool samples compared to biopsy samples. Although results using this assay on biopsy tissue have previously been shown to correspond well with culture and antimicrobial susceptibility testing, there was weak correlation between results obtained using biopsy vs stool samples in our study. Further studies are required to optimise the non-invasive detection of clarithromycin and fluoroquinolone resistant H. pylori infection.
Publish Date 2016-11-06 15:43
Citation Brennan DE, Omorogbe J, Hussey M, Tighe D, Holleran G, O’Morain C, Smith SM, McNamara D. Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples. World J Gastroenterol 2016; 22(41): 9214-9221
URL http://www.wjgnet.com/1007-9327/full/v22/i41/9214.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i41.9214
Full Article (PDF) WJG-22-9214.pdf
Full Article (Word) WJG-22-9214.doc
Manuscript File 29084-Review.docx
Answering Reviewers 29084-Answering reviewers.pdf
Audio Core Tip 29084-Audio core tip.mp3
Biostatistics Review Certificate 29084-Biostatistics statement.pdf
Clinical Trial Registration Statement 29084-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 29084-Conflict-of-interest statement.pdf
Copyright License Agreement 29084-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) Grant_Application_Form_20160809223846.pdf
Signed Informed Consent Form(s) or Document(s) 29084-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 29084-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29084-Language statement.pdf
Peer-review Report 29084-Peer-review(s).pdf
Scientific Misconduct Check 29084-Scientific misconduct check.pdf
Scientific Editor Work List 29084-Scientific editor work list.pdf