Publication Name	World Journal of Gastroenterology
Manuscript ID	2912
Country	China

Received	2013-03-25 08:43
Peer-Review Started	2013-03-26 20:33
To Make the First Decision	2013-04-16 08:58
Return for Revision	2013-04-17 11:34
Revised
Second Decision	2013-07-05 10:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 12:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-07-26 19:09
Typeset the Manuscript	2013-08-07 16:58
Publish the Manuscript Online	2013-08-27 16:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clonality analysis of neuroendocrine cells in gastric adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Ling-Ling Wang, Gen-You Yao, Zhong-Sheng Zhao, Xiao-Li Wei and Ru-Jun Xu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province, China Y2110133 Zhejiang Provincial Medical Science Research Foundation 2010KYA060
Corresponding Author	Gen-You Yao, Professor of Medicine, Institute of Pathology and Forensic Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang Province, China. yaogy@zju.edu.cn
Key Words	Neuroendocrine differentiation; Clonal analysis; Gastric adenocarcinoma; Neuroendocrine cells
Core Tip	There have been only a few studies of neuroendocrine differentiation (NED) in gastric adenocarcinoma. Therefore, we studied the clonality of neuroendocrine (NE) cells in gastric adenocarcinoma using laser capture microdissection, microsatellite instability (MSI), loss of heterozygosity (LOH) and p53 mutation to evaluate the clonality of NED. NE and adenocarcinoma cells showed the same MSI, LOH or p53 mutation in most cases (27/30), they may originate from the same stem cells, but the remaining three cases showed different origins, which warrants further research.
Publish Date	2013-08-27 16:46
Citation	Wang LL, Yao GY, Zhao ZS, Wei XL, Xu RJ. Clonality analysis of neuroendocrine cells in gastric adenocarcinoma. World J Gastroenterol 2013; 19(32): 5340-5346
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5340.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5340

Full Article (PDF)	WJG-19-5340.pdf
Manuscript File	2912-Review.doc
Answering Reviewers	2912-Answering reviewers.pdf
Copyright License Agreement	2912-Copyright assignment.pdf
Peer-review Report	2912-Peer reviews.pdf
Scientific Editor Work List	2912-Scientific editor work list.doc