Publication Name	World Journal of Hepatology
Manuscript ID	29151
Country	United States

Received	2016-07-31 12:36
Peer-Review Started	2016-08-02 11:40
To Make the First Decision	2016-09-02 14:28
Return for Revision	2016-09-08 12:04
Revised	2016-10-02 05:05
Second Decision	2016-11-22 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-02 11:02
Articles in Press	2016-12-02 11:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-22 08:54
Publish the Manuscript Online	2017-02-06 09:08

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha
Manuscript Source	Invited Manuscript
All Author List	Hong Lu, Xiaohong Lei, Jerry Liu and Curtis Klaassen
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health ES019487 (in part)
Corresponding Author	Hong Lu, PhD, Assistant Professor, Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams ST, Syracuse, NY 13210, United States. luh@upstate.edu
Key Words	Liver; Hepatocyte nuclear factor 4 alpha; Knockout; Mice; Human; miR-122; miR-192; miR-194; miR-101; miR-802
Core Tip	Hepatocyte nuclear factor 4 alpha (HNF4α) is a liver-enriched master regulator of liver development and function. HNF4α plays a key role in regulating hepatic transcriptome and epigenome. However, little was known about the role of HNF4α in regulating hepatic expression of microRNAs, essential modulators of the transcriptome and epigenome. Results from this study uncover species differences and similarities between humans and mice in the role of HNF4α in regulating hepatic expression of certain important microRNAs. Such novel knowledge will help understand the role of HNF4α in post-transcriptional regulation of gene expression and maintenance of the normal epigenome and physiology in mouse and human liver.
Publish Date	2017-02-06 09:08
Citation	Lu H, Lei X, Liu J, Klaassen C. Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha. World J Hepatol 2017; 9(4): 191-208
URL	http://www.wjgnet.com/1948-5182/full/v9/i4/191.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i4.191

Full Article (PDF)	WJH-9-191.pdf
Full Article (Word)	WJH-9-191.doc
Manuscript File	29151-Review.doc
Answering Reviewers	29151-Answering reviewers.pdf
Audio Core Tip	29151-Audio core tip.mp3
Biostatistics Review Certificate	29151-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	29151-Conflict-of-interest statement.pdf
Copyright License Agreement	29151-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	29151-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	29151-Institutional animal care and use committee statement.pdf
Supplementary Material	29151-Supplementary material.pdf
Peer-review Report	29151-Peer-review(s).pdf
Scientific Misconduct Check	29151-Scientific misconduct check.pdf
Scientific Editor Work List	29151-Scientific editor work list.pdf