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Articles Published Processes
12/13/2016 12:40:00 AM | Browse: 897 | Download: 1693
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Received |
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2016-08-03 10:17 |
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Peer-Review Started |
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2016-08-03 11:31 |
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To Make the First Decision |
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2016-08-19 15:13 |
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Return for Revision |
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2016-08-23 10:11 |
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Revised |
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2016-09-08 10:34 |
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Second Decision |
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2016-09-30 13:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-10 17:32 |
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Articles in Press |
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2016-10-10 17:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-10-25 06:45 |
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Typeset the Manuscript |
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2016-12-02 17:28 |
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Publish the Manuscript Online |
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2016-12-13 00:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Chang Lei, Chun-Lei Lu, Ling Chen, Ke Ge, Ling-Ling Yang, Wen Li and Yuan-Hua Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260455 |
| National Natural Science Foundation of China |
81160065 |
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| Corresponding Author |
Dr. Yan-Chang Lei, Chief Physician, Department of Infectious Diseases, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, Zhejiang Province, China. ycleihust@sina.com |
| Key Words |
Acute liver failure; C5a/C5aR; p38-MAPK; Sphingosine kinase 1 |
| Core Tip |
Recent studies and our work show that SphK1 and complement activation play an important role in systemic inflammation in acute liver failure (ALF). It has been shown that C5a activates sphingosine kinase 1 (SphK1) in macrophages. However, the mechanism of C5a-induced SphK1 activation is unknown. In this study we found that excessive activation of C5 and up-regulation of C5aR in liver tissue, and the C5a/C5aR pathway is essential for potentiating SphK1 expression through p38 MAPK activation in ALF. To our knowledge, this is the first report of the mechanism of C5a-induced SphK1 activation, which provides a potential immuno therapeutic strategy for ALF in patients. |
| Publish Date |
2016-12-13 00:40 |
| Citation |
Lei YC, Lu CL, Chen L, Ge K, Yang LL, Li W, Wu YH. C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. World J Gastroenterol 2016; 22(46): 10148-10157 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i46/10148.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i46.10148 |
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