Publication Name	World Journal of Clinical Oncology
Manuscript ID	29233
Country	Germany

Received	2016-08-04 09:38
Peer-Review Started	2016-08-05 11:22
To Make the First Decision	2016-09-02 14:16
Return for Revision	2016-09-05 10:42
Revised	2016-09-10 22:06
Second Decision	2016-09-27 16:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-18 17:15
Articles in Press	2016-10-18 17:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-25 13:46
Publish the Manuscript Online	2016-11-29 16:28

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Circulating cytokeratin-positive cells and tumor budding in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Bruno Märkl, Narjes Wilhelms, Matthias Anthuber, Gerhard Schenkirsch, Günter Schlimok and Daniel Oruzio
Funding Agency and Grant Number
Corresponding Author	Dr. med. Bruno Märkl, MD, PhD, Institute of Pathology, Klinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany. bruno.maerkl@klinikum-augsburg.de
Key Words	Colorectal cancer; Circulating cells; Tumor budding; Peripheral blood; Survival
Core Tip	Blood from the mesenteric vein of 56 colorectal specimens was drawn and evaluated for CK18 positive epithelial cells (CK+). CK+ cells and clusters were identified in a high proportion of cases. However, these cells and clusters were not associated with any of the evaluated clinicopathological factors, including surgical technique and tumor budding. Moreover, the occurrence of CK+ cells or clusters had no influence on the cancer specific survival. Immunocytochemical staining for CK18 does not seem to be a specific marker of mesenteric blood cells for prognostic identification of relevant circulating tumor cells.
Publish Date	2016-11-29 16:28
Citation	Märkl B, Wilhelms N, Anthuber M, Schenkirsch G, Schlimok G, Oruzio D. Circulating cytokeratin-positive cells and tumor budding in colorectal cancer. World J Clin Oncol 2016; 7(6): 433-440
URL	http://www.wjgnet.com/2218-4333/full/v7/i6/433.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i6.433

Full Article (PDF)	WJCO-7-433.pdf
Full Article (Word)	WJCO-7-433.doc
Manuscript File	29233-Review.docx
Answering Reviewers	29233-Answering reviewers.pdf
Audio Core Tip	29233-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	29233-Conflict-of-interest statement.pdf
Copyright License Agreement	29233-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160803050116.pdf
Institutional Review Board Approval Form or Document	29233-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29233-Language certificate.pdf
Peer-review Report	29233-Peer-review(s).pdf
Scientific Misconduct Check	29233-Scientific misconduct check.pdf
Scientific Editor Work List	29233-Scientific editor work list.pdf