Publication Name	World Journal of Biological Chemistry
Manuscript ID	29240
Country	France

Received	2016-08-04 17:25
Peer-Review Started	2016-08-05 17:14
To Make the First Decision	2016-09-02 14:16
Return for Revision	2016-09-05 10:54
Revised	2016-09-29 22:44
Second Decision	2016-12-09 15:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-14 17:10
Articles in Press	2016-12-14 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-20 08:28
Publish the Manuscript Online	2017-02-25 15:11

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Nutrition & Dietetics
Manuscript Type	Basic Study
Article Title	L-carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death
Manuscript Source	Invited Manuscript
All Author List	Françoise Le Borgne, Gaétan Ravaut, Arnaud Bernard and Jean Demarquoy
Funding Agency and Grant Number
Corresponding Author	Jean Demarquoy, PhD, Faculté des Science Gabriel, 6 Bd Gabriel, 21000 Dijon, France. jean.demarquoy@u-bourgogne.fr
Key Words	Superoxide anions; Mitochondria; Reactive Autophagy; Muscle; Carnitine; Oxygen species; Cell death
Core Tip	The overall goal of this study was to identify and characterize the protective effect of L-carnitine on oxidative stress in muscle cells. We, first, induced an oxidative stress in cultured muscle cells and parameters associated with the stress were measured. In another set of experiments, cells were treated with L-carnitine and the same parameters measured. The comparison among the data allowed showing that L-carnitine was able to fight against oxidative stress and dramatically limit cell death. In conclusion, our results show that, at least in muscle cells, L-carnitine can be considered as a non-conventional antioxidant.
Publish Date	2017-02-25 15:11
Citation	Le Borgne F, Ravaut G, Bernard A, Demarquoy J. L-carnitine protects C2C12 cells against mitochondrial superoxide over­production and cell death. World J Biol Chem 2017; 8(1): 86-94
URL	http://www.wjgnet.com/1949-8454/full/v8/i1/86.htm
DOI	http://dx.doi.org/10.4331/wjbc.v8.i1.86

Full Article (PDF)	WJBC-8-86.pdf
Full Article (Word)	WJBC-8-86.doc
Manuscript File	29240-Review.docx
Answering Reviewers	29240-Answering reviewers.pdf
Audio Core Tip	29240-Audio core tip.mp3
Biostatistics Review Certificate	29240-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	29240-Conflict-of-interest statement.pdf
Copyright License Agreement	29240-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	29240-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	29240-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29240-Language certificate.pdf
Peer-review Report	29240-Peer-review(s).pdf
Scientific Misconduct Check	29240-Scientific misconduct check.pdf
Scientific Editor Work List	29240-Scientific editor work list.pdf