Publication Name	World Journal of Gastroenterology
Manuscript ID	29259
Country	United States

Received	2016-08-04 17:30
Peer-Review Started	2016-08-05 13:21
To Make the First Decision	2016-11-21 08:42
Return for Revision	2016-11-23 17:01
Revised	2016-12-02 11:56
Second Decision	2017-01-06 13:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-01-11 12:04
Articles in Press	2017-01-11 12:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-10 10:53
Publish the Manuscript Online	2017-03-19 18:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ryoichi Sakiyama, Brandon J Blau and Toshio Miki
Funding Agency and Grant Number	Funding Agency Grant Number Baxter International Foundation/Keck Summer Research Fellowship Award to Blau BJ California Institute for Regenerative Medicine RT3-07670
Corresponding Author	Toshio Miki, MD, PhD, Assistant Professor of Research, Department of Surgery, Keck School of Medicine, University of Southern California 2011 Zonal Avenue, HMR 509A, Los Angeles, CA 90033, United States. toshiomi@usc.edu
Key Words	Artificial liver; Clinical trial; Hepatocytes; Pluripotent stem cells; Bioreactors
Core Tip	The current lack of transplantable donor livers in the world has led to the development of extracorporeal liver support systems as one possible approach to overcome this problem. Bioartificial liver (BAL) support systems require a cell source to replicate human liver function, yet the ideal cell source for this purpose has yet to be determined. Highly-functional hepatocyte-like cells have recently been generated from human pluripotent stem cells, which show promise as a potential cell source in BAL support systems for the treatment of liver failure in the future.
Publish Date	2017-03-19 18:45
Citation	Sakiyama R, Blau BJ, Miki T. Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells. World J Gastroenterol 2017; 23(11): 1974-1979
URL	http://www.wjgnet.com/1007-9327/full/v23/i11/1974.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i11.1974

Full Article (PDF)	WJG-23-1974.pdf
Full Article (Word)	WJG-23-1974.doc
Manuscript File	29259-Review.docx
Answering Reviewers	29259-Answering reviewers.pdf
Audio Core Tip	29259-Audio core tip.wav
Conflict-of-Interest Disclosure Form	29259-Conflict-of-interest statement.PDF
Copyright License Agreement	29259-Copyright assignment.PDF
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	29259-Grant application form(s).pdf
Peer-review Report	29259-Peer-review(s).pdf
Scientific Misconduct Check	29259-Scientific misconduct check.pdf
Scientific Editor Work List	29259-Scientific editor work list.pdf