| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Glaucia Maria M Fernandes, Anelise Russo, Marcela Alcântara Proença, Nathalia Fernanda Gazola, Gabriela Helena Rodrigues, Patrícia Matos Biselli-Chicote, Ana Elizabete Silva, João Gomes Netinho, Érika Cristina Pavarino and Eny Maria Goloni-Bertollo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation (FAPESP) |
2011/23969-1 |
| São Paulo Research Foundation (FAPESP) |
2012/02473-0 |
| Coordination for the Improvement of Higher Education Personnel (CAPES) |
Master grant |
| National Council of Technological and Scientific Development (CNPq) |
310582/2014-8 |
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| Corresponding Author |
Eny Maria Goloni-Bertollo, PhD, Genetics and Molecular Biology Research Unit - UPGEM, Department of Molecular Biology, São José do Rio Preto Medical School, FAMERP, São José do Rio Preto, Av. Brigadeiro Faria Lima, 5416 Vila São Pedro, SP 15090-000, Brazil. eny.goloni@famerp.br |
| Key Words |
Single-nucleotide polymorphisms; Colorectal neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP1A1; Epoxide hydrolases 1 |
| Core Tip |
Sporadic colorectal cancer (SCRC) includes malignancies that occur in the colon and rectum. This type of cancer is the third most common cancer worldwide. The main etiological factors are age over 50 years and tobacco and alcohol consumption. The elimination of environmental carcinogens contained in tobacco, as well as alcohol, requires metabolic activation mediated by xenobiotic-metabolizing enzymes (XMEs). The CYP2E1*5B and CYP2E1*6 polymor-phisms were associated with SCRC, as well as the CYP2E1*5B (C) and CYP2E1*6 (A) haplotype (minor alleles). Polymorphisms in several genes encoding these XMEs may be involved in alterations in gene expression related to important processes of colorectal carcinogenesis such as inflammation and angiogenesis. |
| Publish Date |
2016-12-06 17:24 |
| Citation |
Fernandes GMM, Russo A, Proença MA, Gazola NF, Rodrigues GH, Biselli-Chicote PM, Silva AE, Netinho JG, Pavarino ÉC, Goloni-Bertollo EM. CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms. World J Gastroenterol 2016; 22(45): 9974-9983 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i45/9974.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i45.9974 |
