Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	29385
Country	United States

Received	2016-08-11 09:21
Peer-Review Started	2016-08-11 18:38
To Make the First Decision	2016-09-06 11:15
Return for Revision	2016-09-12 18:07
Revised	2016-09-28 11:53
Second Decision	2016-11-17 16:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-29 09:16
Articles in Press	2016-11-29 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-09 11:03
Publish the Manuscript Online	2017-02-14 21:07

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Anal intraepithelial neoplasia: A review of diagnosis and management
Manuscript Source	Invited Manuscript
All Author List	Joseph R Roberts, Lacey L Siekas and Andrew M Kaz
Funding Agency and Grant Number
Corresponding Author	Andrew M Kaz, MD, Gastroenterology Section, VA Puget Sound Health Care System, 1660 S. Columbian Way, S-111-Gastro, Seattle, WA 98108, United States. andrew.kaz@va.gov
Key Words	Anal cancer; Anal intraepithelial neoplasia; Anal squamous cell carcinoma; Human papillomavirus vaccine; Human papillomavirus
Core Tip	Anal intraepithelial neoplasia (AIN) is the precursor lesion to anal squamous cell carcinoma. AIN incidence is low in the general population, but rivals colon cancer in high risk groups, particularly those with human immunodeficiency virus infection and men who have sex with men. Thus, screening for AIN and early anal cancer and treatment of these lesions at expert centers should be considered in high risk populations. Screening is performed using anal cytology and high resolution anoscopy, and treatment consists of either topical or ablative therapies. Finally, human papillomavirus vaccination appears to reduce the rate of AIN and possibly anal cancer.
Publish Date	2017-02-14 21:07
Citation	Roberts JR, Siekas LL, Kaz AM. Anal intraepithelial neoplasia: A review of diagnosis and management. World J Gastrointest Oncol 2017; 9(2): 50-61
URL	http://www.wjgnet.com/1948-5204/full/v9/i2/50.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i2.50

Full Article (PDF)	WJGO-9-50.pdf
Full Article (Word)	WJGO-9-50.doc
Manuscript File	29385-Review.docx
Answering Reviewers	29385-Answering reviewers.pdf
Audio Core Tip	29385-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29385-Conflict-of-interest statement.pdf
Copyright License Agreement	29385-Copyright assignment.pdf
Peer-review Report	29385-Peer-review(s).pdf
Scientific Misconduct Check	29385-Scientific misconduct check.pdf
Scientific Editor Work List	29385-Scientific editor work list.pdf