BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/6/2016 8:33:00 AM | Browse: 1187 | Download: 2539
 |
Received |
|
2016-08-12 16:14 |
|
Peer-Review Started |
|
2016-08-13 15:19 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2016-09-14 16:22 |
|
Revised |
|
2016-09-26 16:43 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2016-10-13 12:17 |
|
Second Decision by Editor-in-Chief |
|
2016-10-13 14:30 |
|
Final Decision by Editorial Office Director |
|
2016-10-24 15:29 |
|
Articles in Press |
|
2016-10-24 15:29 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2016-11-29 10:27 |
|
Publish the Manuscript Online |
|
2016-12-06 08:34 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
On-treatment quantitative hepatitis B e antigen predicted response to nucleos(t)ide analogues in chronic hepatitis B
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Hua Gao, Qing-Hua Meng, Zhan-Qing Zhang, Ping Zhao, Qing-Hua Shang, Quan Yuan, Yao Li, Juan Deng, Tong Li, Xue-En Liu and Hui Zhuang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major Science and Technology Special Project of China Twelfth Five-year Plan |
2013ZX10002004 |
| Major Science and Technology Special Project of China Twelfth Five-year Plan |
2012ZX10002003 |
|
| Corresponding Author |
Xue-En Liu, MD, Associate Professor, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China. xueenliu@bjmu.edu.cn |
| Key Words |
Response predictor; Quantitative detection; Hepatitis B e antigen; Hepatitis B virus DNA; Chronic hepatitis B; Nucleos(t)ide analogues |
| Core Tip |
Few studies have systematically evaluated quantitative hepatitis B surface antigen, hepatitis B e antigen (HBeAg), hepatitis B core antibody, hepatitis B virus DNA and alanine aminotransferase for predicting treatment response to nucleos(t)ide analogues (NAs) in HBeAg-positive chronic hepatitis B (CHB). In this study, on-treatment HBeAg level as well as its declined value at 24-wk were identified to be the best predictors not only for 96-wk virological response (VR) but also for HBeAg seroconversion (SC). The combination of HBeAg level and its decline at 24-wk strongly predicted 96-wk VR and HBeAg SC with the AUROC of 0.923 and 0.928, respectively. Thus monitoring an early on-treatment HBeAg level and its decline may help to optimize NAs therapy for CHB patients. |
| Publish Date |
2016-12-06 08:34 |
| Citation |
Gao YH, Meng QH, Zhang ZQ, Zhao P, Shang QH, Yuan Q, Li Y, Deng J, Li T, Liu XE, Zhuang H. On-treatment quantitative hepatitis B e antigen predicted response to nucleos(t)ide analogues in chronic hepatitis B. World J Hepatol 2016; 8(34): 1511-1520
|
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i34/1511.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i34.1511 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
