12/6/2016 8:33:00 AM | Browse: 786 | Download: 1650
| Publication Name | World Journal of Hepatology |
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| Manuscript ID | 29412 |
| Country | China |
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| ISSN | 1948-5182 (online) |
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| Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Retrospective Study | ||||||
| Article Title | On-treatment quantitative hepatitis B e antigen predicted response to nucleos(t)ide analogues in chronic hepatitis B | ||||||
| Manuscript Source | Invited Manuscript | ||||||
| All Author List | Yu-Hua Gao, Qing-Hua Meng, Zhan-Qing Zhang, Ping Zhao, Qing-Hua Shang, Quan Yuan, Yao Li, Juan Deng, Tong Li, Xue-En Liu and Hui Zhuang | ||||||
| Funding Agency and Grant Number |
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| Corresponding Author | Xue-En Liu, MD, Associate Professor, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China. xueenliu@bjmu.edu.cn | ||||||
| Key Words | Response predictor; Quantitative detection; Hepatitis B e antigen; Hepatitis B virus DNA; Chronic hepatitis B; Nucleos(t)ide analogues | ||||||
| Core Tip | Few studies have systematically evaluated quantitative hepatitis B surface antigen, hepatitis B e antigen (HBeAg), hepatitis B core antibody, hepatitis B virus DNA and alanine aminotransferase for predicting treatment response to nucleos(t)ide analogues (NAs) in HBeAg-positive chronic hepatitis B (CHB). In this study, on-treatment HBeAg level as well as its declined value at 24-wk were identified to be the best predictors not only for 96-wk virological response (VR) but also for HBeAg seroconversion (SC). The combination of HBeAg level and its decline at 24-wk strongly predicted 96-wk VR and HBeAg SC with the AUROC of 0.923 and 0.928, respectively. Thus monitoring an early on-treatment HBeAg level and its decline may help to optimize NAs therapy for CHB patients. | ||||||
| Publish Date | 2016-12-06 08:34 | ||||||
| Citation | Gao YH, Meng QH, Zhang ZQ, Zhao P, Shang QH, Yuan Q, Li Y, Deng J, Li T, Liu XE, Zhuang H. On-treatment quantitative hepatitis B e antigen predicted response to nucleos(t)ide analogues in chronic hepatitis B. World J Hepatol 2016; 8(34): 1511-1520 | ||||||
| URL | http://www.wjgnet.com/1948-5182/full/v8/i34/1511.htm | ||||||
| DOI | http://dx.doi.org/10.4254/wjh.v8.i34.1511 |
| Full Article (PDF) | WJH-8-1511.pdf |
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| Full Article (Word) | WJH-8-1511.doc |
| Manuscript File | 29412-Review.doc |
| Answering Reviewers | 29412-Answering reviewers.pdf |
| Audio Core Tip | 29412-Audio core tip.mp3 |
| Biostatistics Review Certificate | 29412-Biostatistics statement.pdf |
| Conflict-of-Interest Disclosure Form | 29412-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 29412-Copyright assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 29412-Grant application form(s).pdf |
| Signed Informed Consent Form(s) or Document(s) | Informed_Consent_Statement_20160812151422.doc |
| Institutional Review Board Approval Form or Document | 29412-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 29412-Language certificate.pdf |
| Peer-review Report | 29412-Peer-review(s).pdf |
| Journal Editor-in-Chief Review Report | 29412-Journal editor-in-chief review report.pdf |
| Scientific Editor Work List | 29412-Scientific editor work list.pdf |