| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Observational Study |
| Article Title |
Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hirotaka Konishi, Kazuma Okamoto, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Ryo Morimura, Shuhei Komatsu, Yasutoshi Murayama, Atsushi Shiozaki, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Daisuke Ichikawa, Hitoshi Fujiwara and Eigo Otsuji |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Hirotaka Konishi, MD, PhD, Assistant Researcher, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto city 6028566, Japan. h-koni7@koto.kpu-m.ac.jp |
| Key Words |
Quick-sequential organ failure assessment; Thrombomodulin-α; Gastrointestinal surgery; Systemic inflammatory response syndrome; Acute disseminated intravascular coagulopathy |
| Core Tip |
The present study investigated the efficacy of thrombomodulin (TM)-α for treatment of disse-minated intravascular coagulopathy (DIC) in the field of gastrointestinal surgery. DIC frequently developed within 1 wk of surgery. TM-α was frequently administered within 1 d of the DIC diagnosis and was continued for more than 3 d. The duration of TM-α administration and improvements in DIC-associated parameters at 1 wk were better prognostic factors for 28-d survival. TM-α was administered significantly earlier to patients with severe clinical symptoms. The early administration of TM-α and improvements in DIC parameters were essential for the treatment of DIC. |
| Publish Date |
2017-01-22 11:39 |
| Citation |
Konishi H, Okamoto K, Shoda K, Arita T, Kosuga T, Morimura R, Komatsu S, Murayama Y, Shiozaki A, Kuriu Y, Ikoma H, Nakanishi M, Ichikawa D, Fujiwara H, Otsuji E. Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery. World J Gastroenterol 2017; 23(5): 891-898 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i5/891.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i5.891 |
