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1/5/2017 11:10:00 AM | Browse: 1081 | Download: 1712
Publication Name World Journal of Gastroenterology
Manuscript ID 29465
Country/Territory Japan
Received
2016-08-15 17:23
Peer-Review Started
2016-08-16 16:45
To Make the First Decision
2016-09-20 10:50
Return for Revision
2016-09-20 13:55
Revised
2016-10-03 20:08
Second Decision
2016-10-18 20:26
Accepted by Journal Editor-in-Chief
2016-10-18 22:37
Accepted by Company Editor-in-Chief
2016-10-27 17:24
Articles in Press
2016-10-27 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-21 19:53
Publish the Manuscript Online
2017-01-05 11:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Basic Study
Article Title Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody
Manuscript Source Invited Manuscript
All Author List Yuichi Matsuo, Yasutoshi Kido, Junko Akada, Seiji Shiota, Tran Thanh Binh, Tran Thi Huyen Trang, Ho DQ Dung, Pham Huu Tung, Tran Dinh Tri, Ngo P Minh Thuan, Le Quang Tam, Bui Chi Nam, Vu Van Khien and Yoshio Yamaoka
Funding Agency and Grant Number
Funding Agency Grant Number
The National Institutes of Health DK62813
The Ministry of Education, Culture, Sports, Science, and Technology of Japan 25293104
The Ministry of Education, Culture, Sports, Science, and Technology of Japan 26640114
The Ministry of Education, Culture, Sports, Science, and Technology of Japan 15H02657
The Japan Society for the Promotion of Science Institutional Program for Young Researcher Overseas Visits
The Strategic Funds for the Promotion of Science and Technology from the Japan Science and Technology Agency
Corresponding Author Yamaoka Yoshio, MD, PhD, Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan. yyamaoka@oita-u.ac.jp
Key Words Helicobacter pylori; cagA genotype; Anti-CagA antibody; Enzyme-linked immunosorbent assay; Inflammation; Gastritis
Core Tip We developed a novel East Asian-type CagA enzyme-linked immunosorbent assay (ELISA) to determine whether this method could detect CagA seropositivity with greater sensitivity in East Asian countries than the conventional anti-CagA antibody ELISA, which utilizes Western-type CagA as the antigen. Our findings revealed that conventional CagA ELISA underestimated CagA seropositivity in East Asian countries and the novel CagA ELISA could detect anti-CagA antibodies with higher sensitivity. In addition, the anti-CagA antibody titer tended to correlate with chronic inflammation in the stomach. Therefore, the titer of East Asian CagA ELISA may be a useful marker for predicting chronic inflammation in the gastric mucosa.
Publish Date 2017-01-05 11:10
Citation Matsuo Y, Kido Y, Akada J, Shiota S, Binh TT, Trang TTH, Dung HDQ, Tung PH, Tri TD, Thuan NPM, Tam LQ, Nam BC, Khien VV, Yamaoka Y. Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody. World J Gastroenterol 2017; 23(1): 48-59
URL http://www.wjgnet.com/1007-9327/full/v23/i1/48.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i1.48
Full Article (PDF) WJG-23-48.pdf
Full Article (Word) WJG-23-48.doc
Manuscript File 29465-Review.doc
Answering Reviewers 29465-Answering reviewers.pdf
Audio Core Tip 29465-Audio core tip.wma
Copyright License Agreement 29465-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 29465-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160815160600.docx
Institutional Review Board Approval Form or Document 29465-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29465-Language certificate.pdf
Supplementary Material 29465-Supplementary materials.pdf
Peer-review Report 29465-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 29465-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 29465-Scientific misconduct check.pdf
Scientific Editor Work List 29465-Scientific editor work list.pdf