1/14/2017 10:42:00 AM | Browse: 1162 | Download: 2487
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 29523 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||
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| Manuscript Type | Basic Study | ||||
| Article Title | Role of LAP+CD4+ T cells in the tumor microenvironment of colorectal cancer | ||||
| Manuscript Source | Unsolicited Manuscript | ||||
| All Author List | Wu Zhong, Zhi-Yuan Jiang, Lei Zhang, Jia-Hao Huang, Shi-Jun Wang, Cun Liao, Bin Cai, Li-Sheng Chen, Sen Zhang, Yun Guo, Yun-Fei Cao and Feng Gao | ||||
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| Corresponding Author | Dr. Yun-Fei Cao, Professor, Department of Colorectal and Anal Surgery, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. cyf0016@163.com | ||||
| Key Words | LAP+CD4+ T cells; Colorectal cancer; Tumor microenvironment; Interleukin-10; Transforming growth factor-β | ||||
| Core Tip | Many carcinomas, including colorectal cancer, gastric and nasopharyngeal cancer, are associated with elevated numbers of T regulatory (Treg) cells. It is suggested that Treg cells promote tumor development and metastasis by inhibiting the proliferation of effector T lymphocytes. LAP+CD4+ T cells, a recently identified subset of CD4+ Treg cells, have 50-fold more potent immunosuppressive ability than traditional CD4+CD25+ T cells. Here, we present several lines of evidence correlating LAP+CD4+ T cells with colorectal cancer progression. | ||||
| Publish Date | 2017-01-14 10:27 | ||||
| Citation | Zhong W, Jiang ZY, Zhang L, Huang JH, Wang SJ, Liao C, Cai B, Chen LS, Zhang S, Guo Y, Cao YF, Gao F. Role of LAP+CD4+ T cells in the tumor microenvironment of colorectal cancer. World J Gastroenterol 2017; 23(3): 455-463 | ||||
| URL | http://www.wjgnet.com/1007-9327/full/v23/i3/455.htm | ||||
| DOI | http://dx.doi.org/10.3748/wjg.v23.i3.455 |
| Full Article (PDF) | WJG-23-455.pdf |
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| Full Article (Word) | WJG-23-455.doc |
| Manuscript File | 29523-Review.doc |
| Answering Reviewers | 29523-Audio core tip.mp3 |
| Audio Core Tip | 29523-Audio core tip.mp3 |
| Biostatistics Review Certificate | 29523-Biostatistics statement.pdf |
| Conflict-of-Interest Disclosure Form | 29523-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 29523-Copyright assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 29523-Grant application form(s).pdf |
| Signed Informed Consent Form(s) or Document(s) | Informed_Consent_Statement_20160818131154.doc |
| Institutional Animal Care and Use Committee Approval Form or Document | 29523-Institutional animal care and use committee statement.pdf |
| Institutional Review Board Approval Form or Document | 29523-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 29523-Language certificate.pdf |
| Peer-review Report | 29523-Peer-review(s).pdf |
| Scientific Misconduct Check | 29523-Scientific misconduct check.pdf |
| Scientific Editor Work List | 29523-Scientific editor work list.pdf |