Publication Name	World Journal of Hepatology
Manuscript ID	29539
Country	Russia

Received	2016-08-19 11:08
Peer-Review Started	2016-08-19 17:36
To Make the First Decision	2016-09-13 14:07
Return for Revision	2016-09-13 19:43
Revised	2016-09-23 18:41
Second Decision	2016-10-21 10:26
Accepted by Journal Editor-in-Chief	2016-10-22 13:29
Accepted by Executive Editor-in-Chief	2016-11-02 16:05
Articles in Press	2016-11-02 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-20 10:07
Publish the Manuscript Online	2016-12-27 08:31

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Restructuring of the vascular bed in response to hemodynamic disturbances in portal hypertension
Manuscript Source	Invited Manuscript
All Author List	Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev and Dmitry Vladimirovich Belov
Funding Agency and Grant Number
Corresponding Author	Dmitry Victorovich Garbuzenko, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, Box 12317, 454092 Chelyabinsk, Russia. garb@inbox.ru
Key Words	Portal hypertension; Vascular Remodeling; Angiogenesis; Pathogenesis; Liver cirrhosis
Core Tip	The purpose of the review is to describe the mechanisms of restructuring of the vascular bed in response to hemodynamic disturbances in portal hyper-tension. In addition to pathophysiological disorders related to endothelial dysfunction, it was revealed: There is the restructuring of the vasculature, which includes vascular remodeling and angiogenesis. In spite of the fact that these changes are the compensatory-adaptive response to the deteriorating conditions of blood circulation, taken together, they contribute to the development and progression of portal hypertension causing severe complications such as bleeding from esophageal varices.
Publish Date	2016-12-27 08:31
Citation	Garbuzenko DV, Arefyev NO, Belov DV. Restructuring of the vascular bed in response to hemodynamic disturbances in portal hypertension. World J Hepatol 2016; 8(36): 1602-1609
URL	http://www.wjgnet.com/1948-5182/full/v8/i36/1602.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i36.1602

Full Article (PDF)	WJH-8-1602.pdf
Full Article (Word)	WJH-8-1602.doc
Manuscript File	29539-Review.doc
Answering Reviewers	29539-Answering reviewers.pdf
Audio Core Tip	29539-Audio core tip.wav
Conflict-of-Interest Disclosure Form	29539-Conflict-of-interest statement.pdf
Copyright License Agreement	29539-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29539-Language certificate.pdf
Peer-review Report	29539-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29539-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29539-Scientific misconduct check.pdf
Scientific Editor Work List	29539-Scientific editor work list.pdf