Publication Name	World Journal of Clinical Cases
Manuscript ID	29545
Country	Italy

Received	2016-08-19 10:39
Peer-Review Started	2016-08-20 12:46
To Make the First Decision	2016-10-21 08:51
Return for Revision	2016-10-21 10:42
Revised	2016-10-27 01:33
Second Decision	2016-11-10 14:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-22 15:05
Articles in Press	2016-11-22 15:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-09 19:19
Publish the Manuscript Online	2017-02-16 13:41

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Externalized conductors and insulation failure in Biotronik defibrillator leads: History repeating or a false alarm?
Manuscript Source	Invited Manuscript
All Author List	Elia De Maria, Ambra Borghi, Lorenzo Bonetti, Pier Luigi Fontana and Stefano Cappelli
Funding Agency and Grant Number
Corresponding Author	Elia De Maria, MD, PhD, Chief of Arrhythmology Lab, Cardiology Unit, Ramazzini Hospital, Via Molinari 1, 41012 Carpi (Modena), Italy. e.demaria@inwind.it
Key Words	Implantable cardioverter defibrillator; Biotronik implantable cardioverter defibrillator lead; Externalized conductors; Insulation failure
Core Tip	Conductor externalization and insulation failure are frequent complications with the recalled St. Jude Medical Riata implantable cardioverter-defibrillator leads. Cables can externalize through the insulation (“inside-out” abrasion) and appear outside the lead body. Recently similar failure mechanisms have also been described for Biotronik leads. Some studies reported a high rate of electrical dysfunction (including insulation failure) with Biotronik Linox leads and a survival rate between 88% and 91% at 5 years, significantly worse than that of other manufacturers. However, the preliminary results of two ongoing multicenter, prospective registries showed 96% survival rate at 5 years, well within industry standards.
Publish Date	2017-02-16 13:41
Citation	De Maria E, Borghi A, Bonetti L, Fontana PL, Cappelli S. Externalized conductors and insulation failure in Biotronik defibrillator leads: History repeating or a false alarm? World J Clin Cases 2017; 5(2): 27-34
URL	http://www.wjgnet.com/2307-8960/full/v5/i2/27.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i2.27

Full Article (PDF)	WJCC-5-27.pdf
Full Article (Word)	WJCC-5-27.doc
Manuscript File	29545-Review.doc
Answering Reviewers	29545-Answering reviewers.pdf
Audio Core Tip	29545-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29545-Conflict-of-interest statement.pdf
Copyright License Agreement	29545-Copyright assignment.pdf
Peer-review Report	29545-Peer-review(s).pdf
Scientific Misconduct Check	29545-Scientific misconduct check.pdf
Scientific Editor Work List	29545-Scientific editor work list.pdf