Publication Name	World Journal of Biological Chemistry
Manuscript ID	29608
Country	Japan

Received	2016-08-22 20:54
Peer-Review Started	2016-08-24 09:26
To Make the First Decision	2016-11-11 08:55
Return for Revision	2016-11-19 19:56
Revised	2016-12-02 14:44
Second Decision	2017-03-07 15:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-17 14:02
Articles in Press	2017-03-17 14:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-16 01:42
Publish the Manuscript Online	2017-05-18 04:11

ISSN	1949-8454 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Immunological aspects of age-related diseases
Manuscript Source	Invited Manuscript
All Author List	Ken-ichi Isobe, Naomi Nishio and Tadao Hasegawa
Funding Agency and Grant Number
Corresponding Author	Ken-ichi Isobe, MD, PhD, Professor, Department of Food Science and Nutrition, Nagoya Woman’s University, 3-40 Shioji-cho, Mizuho-ku, Nagoya 467-8610, Japan. isobe@nagoya-wu.ac.jp
Key Words	Elderly people; Damage associated molecular patterns; Immune dysfunction; Lymphoid lineage; Myeloid lineage; Shrinkage of thymus; Cytomegalovirus; Age-related tissue damage; Cellular senescence; Pro-inflammatory
Core Tip	The authors divide immune cells, which are involved in age-related pathological changes, into two categories. First category is aging of immune cell-itself, which include age-related myeloid lineage deviation of hematopoietic stem cells, the shrinkage of thymus followed by the decline of naïve T cells, the cytomegalovirus infection-mediated decline of T-cell receptor repertoire diversity and functional decline of myeloid cells. Second category is the involvement of immune cells to age-related pathological changes. Age-related tissue damage and cellular senescence activate pro-inflammatory (M1) macrophages, which induce many age-related diseases. Biochemical works are needed to further elucidate age-related immune changes.
Publish Date	2017-05-18 04:11
Citation	Isobe K, Nishio N, Hasegawa T. Immunological aspects of age-related diseases. World J Biol Chem 2017; 8(2): 129-137
URL	http://www.wjgnet.com/1949-8454/full/v8/i2/129.htm
DOI	http://dx.doi.org/10.4331/wjbc.v8.i2.129

Full Article (PDF)	WJBC-8-129.pdf
Full Article (Word)	WJBC-8-129.doc
Manuscript File	29608-Review.docx
Answering Reviewers	29608-Answering reviewers.pdf
Audio Core Tip	29608-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29608-Conflict-of-interest statement.pdf
Copyright License Agreement	29608-Copyright assignment.pdf
Peer-review Report	29608-Peer-review(s).pdf
Scientific Misconduct Check	29608-Scientific misconduct check.pdf
Scientific Editor Work List	29608-Scientific editor work list.pdf