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12/6/2016 5:24:00 PM | Browse: 1091 | Download: 1240
Publication Name World Journal of Gastroenterology
Manuscript ID 29638
Country/Territory China
Received
2016-08-24 10:44
Peer-Review Started
2016-08-25 15:16
To Make the First Decision
2016-09-12 16:41
Return for Revision
2016-09-13 18:03
Revised
2016-09-26 14:25
Second Decision
2016-10-25 20:03
Accepted by Journal Editor-in-Chief
2016-10-27 18:07
Accepted by Company Editor-in-Chief
2016-10-31 15:07
Articles in Press
2016-10-31 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-11-08 10:02
Typeset the Manuscript
2016-11-22 13:18
Publish the Manuscript Online
2016-12-06 17:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Understanding the role of PIN1 in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Chi-Wai Cheng, Ka-Wai Leong and Eric Tse
Funding Agency and Grant Number
Corresponding Author Eric Tse, MBBS, PhD, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. ewctse@hku.hk
Key Words Phosphorylation; Hepatocellular carcinoma; PIN1; Isomerization; Hepatocarcinogenesis
Core Tip PIN1 specifically binds and catalyses iso-merization of the pSer/Thr-Pro motif of target pro-teins, thereby modulating their functions. Many PIN1-interacting proteins are involved in cellular transformation and maintenance of malignant phenotype, and overexpression of PIN1 is frequently found in various cancer types, including hepatocellular carcinoma (HCC). Through interacting with regulatory proteins of key signalling pathways, such as β-catenin, cyclin D1, and HBx, PIN1 drives and amplifies the oncogenic signals essential for the development of HCC. Given its diverse oncogenic functions in hepatocarcinogenesis, PIN1 represents a potential therapeutic target in the treatment of HCC.
Publish Date 2016-12-06 17:24
Citation Cheng CW, Leong KW, Tse E. Understanding the role of PIN1 in hepatocellular carcinoma. World J Gastroenterol 2016; 22(45): 9921-9932
URL http://www.wjgnet.com/1007-9327/full/v22/i45/9921.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i45.9921
Full Article (PDF) WJG-22-9921.pdf
Full Article (Word) WJG-22-9921.doc
Manuscript File 29638-Review.docx
Answering Reviewers 29638-Answering reviewers.pdf
Audio Core Tip 29638-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 29638-Conflict-of-interest statement.pdf
Copyright License Agreement 29638-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 29638-Language certificate.pdf
Peer-review Report 29638-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 29638-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 29638-Scientific misconduct check.pdf
Scientific Editor Work List 29638-Scientific editor work list.pdf