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Articles Published Processes
12/6/2016 5:24:00 PM | Browse: 1091 | Download: 1240
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Received |
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2016-08-24 10:44 |
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Peer-Review Started |
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2016-08-25 15:16 |
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To Make the First Decision |
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2016-09-12 16:41 |
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Return for Revision |
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2016-09-13 18:03 |
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Revised |
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2016-09-26 14:25 |
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Second Decision |
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2016-10-25 20:03 |
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Accepted by Journal Editor-in-Chief |
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2016-10-27 18:07 |
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Accepted by Company Editor-in-Chief |
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2016-10-31 15:07 |
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Articles in Press |
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2016-10-31 15:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-11-08 10:02 |
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Typeset the Manuscript |
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2016-11-22 13:18 |
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Publish the Manuscript Online |
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2016-12-06 17:24 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Review |
Article Title |
Understanding the role of PIN1 in hepatocellular carcinoma
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Manuscript Source |
Invited Manuscript |
All Author List |
Chi-Wai Cheng, Ka-Wai Leong and Eric Tse |
Funding Agency and Grant Number |
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Corresponding Author |
Eric Tse, MBBS, PhD, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. ewctse@hku.hk
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Key Words |
Phosphorylation; Hepatocellular carcinoma; PIN1; Isomerization; Hepatocarcinogenesis |
Core Tip |
PIN1 specifically binds and catalyses iso-merization of the pSer/Thr-Pro motif of target pro-teins, thereby modulating their functions. Many PIN1-interacting proteins are involved in cellular transformation and maintenance of malignant phenotype, and overexpression of PIN1 is frequently found in various cancer types, including hepatocellular carcinoma (HCC). Through interacting with regulatory proteins of key signalling pathways, such as β-catenin, cyclin D1, and HBx, PIN1 drives and amplifies the oncogenic signals essential for the development of HCC. Given its diverse oncogenic functions in hepatocarcinogenesis, PIN1 represents a potential therapeutic target in the treatment of HCC.
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Publish Date |
2016-12-06 17:24 |
Citation |
Cheng CW, Leong KW, Tse E. Understanding the role of PIN1 in hepatocellular carcinoma. World J Gastroenterol 2016; 22(45): 9921-9932 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i45/9921.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i45.9921 |
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