Publication Name	World Journal of Gastroenterology
Manuscript ID	29664
Country	Poland

Received	2016-08-24 09:05
Peer-Review Started	2016-08-25 16:49
To Make the First Decision	2016-09-12 16:41
Return for Revision	2016-09-13 18:15
Revised	2016-10-26 00:00
Second Decision	2017-02-15 18:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-17 10:22
Articles in Press	2017-02-17 10:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-27 20:24
Publish the Manuscript Online	2017-03-06 13:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Frontier
Article Title	Host pathogen interactions in Helicobacter pylori related gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Magdalena Chmiela, Zuzanna Karwowska, Weronika Gonciarz, Bujana Allushi and Paweł Stączek
Funding Agency and Grant Number
Corresponding Author	Magdalena Chmiela, PhD, Professor, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. chmiela@biol.uni.lodz.pl
Key Words	Helicobacter pylori; host susceptibility; carcinogenesis; bacterial diversity
Core Tip	In 1994 Helicobacter pylori (H. pylori) was classified by the International Agency for Research of Cancer as a class I human carcinogen for gastric cancer. Nearly 60% of the intestinal type gastric cancers are associated with H. pylori infections. Cancer risk rises if strain possess virulence factors: CagA, VacA and BabA. These bacteria promotes gastric carcinogenesis by increased DNA damage, impairment of repair processes, induction of mitochondrial DNA and genomic mutations. Nearly 98% of mucosa associated lymphoid tissue lymphomas are H. pylori dependent. We discuss correlation between H. pylori and gastric cancer in the light of bacterial and host genetic variability.
Publish Date	2017-03-06 13:24
Citation	Chmiela M, Karwowska Z, Gonciarz W, Allushi B, Stączek P. Host pathogen interactions in Helicobacter pylori related gastric cancer. World J Gastroenterol 2017; 23(9): 1521-1540
URL	http://www.wjgnet.com/1007-9327/full/v23/i9/1521.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i9.1521

Full Article (PDF)	WJG-23-1521.pdf
Full Article (Word)	WJG-23-1521.doc
Manuscript File	29664-Review.doc
Answering Reviewers	29664-Answering reviewers.pdf
Audio Core Tip	29664-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29664-Conflict-of-interest statement.pdf
Copyright License Agreement	29664-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29664-Language certificate.pdf
Peer-review Report	29664-Peer-review(s).pdf
Scientific Misconduct Check	29664-Scientific misconduct check.pdf
Scientific Editor Work List	29664-Scientific editor work list.pdf