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Articles Published Processes
11/18/2016 3:13:00 PM | Browse: 1001 | Download: 2198
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Received |
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2016-08-24 11:01 |
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Peer-Review Started |
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2016-08-24 20:31 |
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To Make the First Decision |
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2016-09-06 16:34 |
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Return for Revision |
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2016-09-08 11:47 |
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Revised |
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2016-09-20 17:29 |
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Second Decision |
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2016-10-10 13:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-19 17:26 |
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Articles in Press |
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2016-10-19 17:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-11-01 16:15 |
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Typeset the Manuscript |
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2016-11-14 15:43 |
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Publish the Manuscript Online |
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2016-11-18 15:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Song Hu, Li-Bin Jiang, Xiao-Jing Zou, Wei Yi and De-Ying Tian |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81171559 |
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| Corresponding Author |
De-Ying Tian, PhD, Professor, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430030, Hubei Province, China. dytian@tjh.tjmu.edu.cn |
| Key Words |
Hepatitis B; Pattern recognition receptors; α-Mannosidase; Glycosylation; Dendritic cells |
| Core Tip |
To date, few studies have investigated whether hepatitis B virus (HBV) hijacks the host hepatocyte’s demannosylation system to trim the mannose oligosaccharides found on its viral envelope, thereby evading DC-SIGN recognition. Our study showed that HBV could increase the expression of α-mannosidase I both in vitro and in vivo. Moreover, the HBV envelope protein increases the expression of α-mannosidase I via the PPARα pathway. Therefore, α-mannosidase I may be a novel drug target to inhibit the demannosylation of HBV, and prevent viral escape. |
| Publish Date |
2016-11-18 15:13 |
| Citation |
Hu S, Jiang LB, Zou XJ, Yi W, Tian DY. Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway. World J Gastroenterol 2016; 22(43): 9534-9543 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i43/9534.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i43.9534 |
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