Publication Name	World Journal of Gastroenterology
Manuscript ID	29674
Country	China

Received	2016-08-24 11:01
Peer-Review Started	2016-08-24 20:31
To Make the First Decision	2016-09-06 16:34
Return for Revision	2016-09-08 11:47
Revised	2016-09-20 17:29
Second Decision	2016-10-10 13:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-19 17:26
Articles in Press	2016-10-19 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-11-01 16:15
Typeset the Manuscript	2016-11-14 15:43
Publish the Manuscript Online	2016-11-18 15:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Virology
Manuscript Type	Basic Study
Article Title	Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Song Hu, Li-Bin Jiang, Xiao-Jing Zou, Wei Yi and De-Ying Tian
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81171559
Corresponding Author	De-Ying Tian, PhD, Professor, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430030, Hubei Province, China. dytian@tjh.tjmu.edu.cn
Key Words	Hepatitis B; Pattern recognition receptors; α-Mannosidase; Glycosylation; Dendritic cells
Core Tip	To date, few studies have investigated whether hepatitis B virus (HBV) hijacks the host hepatocyte’s demannosylation system to trim the mannose oligosaccharides found on its viral envelope, thereby evading DC-SIGN recognition. Our study showed that HBV could increase the expression of α-mannosidase I both in vitro and in vivo. Moreover, the HBV envelope protein increases the expression of α-mannosidase I via the PPARα pathway. Therefore, α-mannosidase I may be a novel drug target to inhibit the demannosylation of HBV, and prevent viral escape.
Publish Date	2016-11-18 15:13
Citation	Hu S, Jiang LB, Zou XJ, Yi W, Tian DY. Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway. World J Gastroenterol 2016; 22(43): 9534-9543
URL	http://www.wjgnet.com/1007-9327/full/v22/i43/9534.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i43.9534

Full Article (PDF)	WJG-22-9534.pdf
Full Article (Word)	WJG-22-9534.doc
Manuscript File	29674-Review.doc
Answering Reviewers	29674-Answering reviewers.pdf
Audio Core Tip	29674-Audio core tip.MP3
Biostatistics Review Certificate	29674-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	29674-Conflict-of-interest statement.pdf
Copyright License Agreement	29674-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	29674-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	29674-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29674-Language certificate.pdf
Peer-review Report	29674-Peer-review(s).pdf
Scientific Misconduct Check	29674-Scientific misconduct check.pdf
Scientific Editor Work List	29674-Scientific editor work list.pdf