Publication Name	World Journal of Clinical Cases
Manuscript ID	29691
Country	Japan

Received	2016-08-25 10:13
Peer-Review Started	2016-08-25 20:55
To Make the First Decision	2016-10-28 11:32
Return for Revision	2016-11-01 10:59
Revised	2016-11-11 21:41
Second Decision	2016-11-22 17:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-02 10:36
Articles in Press	2016-12-02 10:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-03 08:39
Publish the Manuscript Online	2017-01-09 11:21

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Case Report
Article Title	Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy: A case report and literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Nobuhisa Takase, Kimihiro Yamashita, Yasuo Sumi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yu-Ichiro Koma, Masato Komatsu, Ryohei Sasaki and Yoshihiro Kakeji
Funding Agency and Grant Number
Corresponding Author	Kimihiro Yamashita, MD, PhD, Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. kiyama@med.kobe-u.ac.jp
Key Words	Local advanced rectal cancer; Preoperative chemoradiotherapy; Rectal perforation; 5-fluorouracil; Tumor necrosis
Core Tip	Standard chemoradiotherapy (CRT) for local advanced rectal cancer (LARC) rarely induces rectal perforation. This case report presents a case of rectal perforation in a patient with LARC in the midst of 5-fluo-rouracil-based preoperative CRT. We decided to com-plete CRT according to the original plan after supporting emer-gency recovery. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis, suggesting the efficacy of the CRT. We believe that establishing a standard treatment for CRT-related LARC perforation may improve the prognosis of such cases.
Publish Date	2017-01-09 11:21
Citation	Takase N, Yamashita K, Sumi Y, Hasegawa H, Yamamoto M, Kanaji S, Matsuda Y, Matsuda T, Oshikiri T, Nakamura T, Suzuki S, Koma YI, Komatsu M, Sasaki R, Kakeji Y. Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy: A case report and literature review. World J Clin Cases 2017; 5(1): 18-23
URL	http://www.wjgnet.com/2307-8960/full/v5/i1/18.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i1.18

Full Article (PDF)	WJCC-5-18.pdf
Full Article (Word)	WJCC-5-18.doc
Manuscript File	29691-Review.docx
Answering Reviewers	29691-Answering reviewers.pdf
Audio Core Tip	29691-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	29691-Conflict-of-interest statement.pdf
Copyright License Agreement	29691-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	29691-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29691-Language certificate.pdf
Peer-review Report	29691-Peer-review(s).pdf
Scientific Misconduct Check	29691-Scientific misconduct check.pdf
Scientific Editor Work List	29691-Scientific editor work list.pdf