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Articles Published Processes
1/12/2017 1:49:00 PM | Browse: 1364 | Download: 1870
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Received |
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2016-08-26 11:06 |
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Peer-Review Started |
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2016-08-28 21:44 |
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To Make the First Decision |
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2016-09-21 15:16 |
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Return for Revision |
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2016-09-23 15:52 |
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Revised |
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2016-09-29 10:50 |
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Second Decision |
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2016-10-24 16:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-31 15:30 |
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Articles in Press |
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2016-10-31 15:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-11-19 07:24 |
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Typeset the Manuscript |
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2016-12-31 14:28 |
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Publish the Manuscript Online |
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2017-01-12 13:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Mitochondrial carnitine palmitoyl transferase-Ⅱ inactivity aggravates lipid accumulation in rat hepatocarcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juan-Juan Gu, Min Yao, Jie Yang, Yin Cai, Wen-Jie Zheng, Li Wang, Deng-Bing Yao and Deng-Fu Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation |
81673241 |
| National Natural Science Foundation |
81200634 |
| National Natural Science Foundation |
81370982 |
| program of Jiangsu Key Research Plan |
BE2016698 |
| International Science and Technology Cooperation Program |
2013DFA32150 |
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| Corresponding Author |
Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Fatty liver; Carnitine palmitoyl transferase-Ⅱ; Malignant transformation of hepatocytes; Dynamic expression; Rat model |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is one of the main risk factors for hepatocellular car-cinoma, except for chronic infection with hepatitis B virus or hepatitis C virus as well as other non-viral liver diseases. However, the pathogenesis of NAFLD formation still need to be elucidated. We have successfully investigated the dynamic alteration of carnitine palmitoyl transferase Ⅱ (CPT-Ⅱ) expression located on the mitochondrial inner membrane during malignant transformation of rat hepatocytes under lipid accumulation and first discovered that the progressively decreasing of CPT-Ⅱ expression in hepatocarcinogenesis might lead to abnormal hepatic lipid accumulation and promote the malignant transformation of hepatocytes. |
| Publish Date |
2017-01-12 13:49 |
| Citation |
Gu JJ, Yao M, Yang J, Cai Y, Zheng WJ, Wang L, Yao DB, Yao DF. Mitochondrial carnitine palmitoyl transferase-Ⅱ inactivity aggravates lipid accumulation in rat hepatocarcinogenesis. World J Gastroenterol 2017; 23(2): 256-264 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i2/256.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i2.256 |
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