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Articles Published Processes
1/22/2017 11:39:00 AM | Browse: 1276 | Download: 2069
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Received |
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2016-08-26 08:54 |
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Peer-Review Started |
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2016-08-28 20:56 |
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To Make the First Decision |
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2016-10-20 13:00 |
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Return for Revision |
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2016-10-21 10:54 |
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Revised |
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2016-10-22 20:19 |
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Second Decision |
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2016-11-11 14:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-11-16 16:31 |
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Articles in Press |
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2016-11-16 16:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-12 18:29 |
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Publish the Manuscript Online |
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2017-01-22 11:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Thorsten Brechmann, Andre Sperlbaum and Wolff Schmiegel |
| Funding Agency and Grant Number |
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| Corresponding Author |
Thorsten Brechmann, MD, Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. thorsten.brechmann@rub.de |
| Key Words |
Bacterial overgrowth syndrome; Hydrogen breath tests; Immunosuppression; Intestinal motility; Hypothyroidism |
| Core Tip |
Several contributors to small intestinal overgrowth have been described, but the impact of par-ticular risk factors is poorly understood. We aimed to determine the influence of several pathomechanisms, such as impaired gastric acid barrier function, impaired intestinal clearance, impairment of defence mechanisms and miscellaneous factors, as well as to weight and rank a large set of potential contributors by means of a retrospective cohort study of 1809 consecutive patients who had undergone a hydrogen breath test to rule out small intestinal bacterial overgrowth. Overall, levothyroxine therapy, impaired intestinal clearance and immunosuppression are the strongest contributors, while an impaired gastric acid barrier only plays a minor role. |
| Publish Date |
2017-01-22 11:39 |
| Citation |
Brechmann T, Sperlbaum A, Schmiegel W. Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study. World J Gastroenterol 2017; 23(5): 842-852 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i5/842.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i5.842 |
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