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1/22/2017 11:39:00 AM | Browse: 436 | Download: 518
Publication Name World Journal of Gastroenterology
Manuscript ID 29738
Country/Territory Germany
Received
2016-08-26 08:54
Peer-Review Started
2016-08-28 20:56
To Make the First Decision
2016-10-20 13:00
Return for Revision
2016-10-21 10:54
Revised
2016-10-22 20:19
Second Decision
2016-11-11 14:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-11-16 16:31
Articles in Press
2016-11-16 16:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-01-12 18:29
Publish the Manuscript Online
2017-01-22 11:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study
Manuscript Source Unsolicited Manuscript
All Author List Thorsten Brechmann, Andre Sperlbaum and Wolff Schmiegel
Funding Agency and Grant Number
Corresponding author Thorsten Brechmann, MD, Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. thorsten.brechmann@rub.de
Keywords Bacterial overgrowth syndrome; Hydrogen breath tests; Immunosuppression; Intestinal motility; Hypothyroidism
Core Tip Several contributors to small intestinal overgrowth have been described, but the impact of par-ticular risk factors is poorly understood. We aimed to determine the influence of several pathomechanisms, such as impaired gastric acid barrier function, impaired intestinal clearance, impairment of defence mechanisms and miscellaneous factors, as well as to weight and rank a large set of potential contributors by means of a retrospective cohort study of 1809 consecutive patients who had undergone a hydrogen breath test to rule out small intestinal bacterial overgrowth. Overall, levothyroxine therapy, impaired intestinal clearance and immunosuppression are the strongest contributors, while an impaired gastric acid barrier only plays a minor role.
Publish Date 2017-01-22 11:39
Citation Brechmann T, Sperlbaum A, Schmiegel W. Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study. World J Gastroenterol 2017; 23(5): 842-852
Url http://www.wjgnet.com/1007-9327/full/v23/i5/842.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i5.842
Full Article (PDF) WJG-23-842.pdf
Full Article (Word) WJG-23-842.doc
Manuscript File 29738-Review.docx
Answering Reviewers 29738-Answering reviewers.pdf
Audio Core Tip 29738-Audio core tip.mp3
Biostatistics Review Certificate 29738-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 29738-Conflict-of-interest statement.pdf
Copyright License Agreement 29738-Copyright assignment.pdf
Data Sharing Statement 29738-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 29738-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160826021521.pdf
Institutional Review Board Approval Form or Document 29738-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20160826021352.pdf
Scientific Research Process 29738-Scientific research process.pdf
Peer-review Report 29738-Peer-review(s).pdf
Scientific Misconduct Check 29738-Scientific misconduct check.pdf
Scientific Editor Work List 29738-Scientific editor work list.pdf