Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	2975
Country	United Kingdom

Received	2013-03-29 12:26
Peer-Review Started	2013-03-29 14:41
To Make the First Decision	2013-04-16 09:16
Return for Revision	2013-04-18 19:39
Revised	2013-04-24 04:05
Second Decision	2013-06-18 09:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-19 00:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-11 00:33
Publish the Manuscript Online	2013-11-17 20:09

ISSN	2218-6220 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Obstetrics & Gynecology
Manuscript Type	Therapeutics Advances
Article Title	Folic acid supplementation: The new dawn for postmenopausal women with hot flushes
Manuscript Source	Invited Manuscript
All Author List	Ayman AA Ewies
Funding Agency and Grant Number
Corresponding Author	Ayman A A Ewies, MBChB, MSc, FRCOG, MD, Consultant Gynaecologist, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham City Hospital, Dudley Road, Birmingham B18 7QH, West Midlands, United Kingdom. aymanewies@hotmail.com
Key Words	Folic acid; Hot flushes; Menopause; Noradrenaline; Serotonin
Core Tip	Hormone replacement therapy usage by postmenopausal women with hot flushes causes concerns over possible increased risks particularly breast cancer. The improved longevity of women in general and breast cancer survivors in particular, and the limited success shown by the non-hormonal alternatives made it imperative to find a therapy that is effective and safe. It is hypothesized that folic acid supplementation may ameliorate hot flushes by the same mechanism as estrogen supplementation, i.e., by reducing noradrenaline and increasing serotonin neurotransmitters. This article discusses the rationale, potential role, mechanisms of action and safety issues related to its use in these women.
Publish Date	2013-11-17 20:09
Citation	Ewies AAA. Folic acid supplementation: The new dawn for postmenopausal women with hot flushes. World J Obstet Gynecol 2013; 2(4): 87-93
URL	http://www.wjgnet.com/2218-6220/full/v2/i4/87.htm
DOI	http://dx.doi.org/10.5317/wjog.v2.i4.87

Full Article (PDF)	WJOG-2-87.pdf
Manuscript File	2975-Review.doc
Answering Reviewers	2975-Answering reviewers.doc
Copyright License Agreement	2975-Copyright assignment.pdf
Peer-review Report	2975-Peer review(s).docx
Scientific Editor Work List	2975-Scientific editor work list.doc