Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	29765
Country	Spain

Received	2016-08-27 13:48
Peer-Review Started	2016-08-27 23:19
To Make the First Decision	2016-10-20 08:43
Return for Revision	2016-10-28 12:32
Revised	2016-11-03 20:09
Second Decision	2016-11-22 17:46
Accepted by Journal Editor-in-Chief	2016-11-22 20:02
Accepted by Executive Editor-in-Chief	2016-12-02 11:03
Articles in Press	2016-12-02 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-15 10:15
Publish the Manuscript Online	2017-02-24 09:02

ISSN	2220-3176 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Editorial
Article Title	Is it enough to eliminate hepatitis C virus to reverse the damage caused by the infection?
Manuscript Source	Invited Manuscript
All Author List	Patricia Pérez-Matute and José A Oteo
Funding Agency and Grant Number
Corresponding Author	José A Oteo, MD, PhD, Head of the Infectious Disease Department, Center for Biomedical Research of La Rioja (CIBIR)-Hospital San Pedro, c/Piqueras, 98, 26006 Logroño, La Rioja, Spain. jaoteo@riojasalud.es
Key Words	Hepatitis C infection; Inflammation; Virus eradication; Direct-acting antivirals; Gut microbiota
Core Tip	Hepatitis C infection represents one of the major causes of chronic liver disease, hepatocellular car-cinoma and morbidity/mortality worldwide. A complete elimination of the hepatitis C virus (HCV) from the body through treatment is now possible. However, HCV not only alters the hepatic function. In fact, changes in gut microbiota composition (GM) and gut barrier that leads to an increased bacterial translocation and inflammation have also been observed. Thus, a successful treatment of HCV infection should be accompanied by a complete restoration of GM and inflammation. Studies focused on GM after HCV eradication are lacking, which opens unique opportunities to deeply explore this exciting field.
Publish Date	2017-02-24 09:02
Citation	Pérez-Matute P, Oteo JA. Is it enough to eliminate hepatitis C virus to reverse the damage caused by the infection? World J Clin Infect Dis 2017; 7(1): 1-5
URL	http://www.wjgnet.com/2220-3176/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.5495/wjcid.v7.i1.1

Full Article (PDF)	WJCID-7-1.pdf
Full Article (Word)	WJCID-7-1.doc
Manuscript File	29765-Review.doc
Answering Reviewers	29765-Answering reviewers.pdf
Audio Core Tip	29765-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	29765-Conflict-of-interest statement.pdf
Copyright License Agreement	29765-Copyright assignment.pdf
Peer-review Report	29765-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29765-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29765-Scientific misconduct check.pdf
Scientific Editor Work List	29765-Scientific editor work list.pdf