Publication Name	World Journal of Gastroenterology
Manuscript ID	29773
Country	United States

Received	2016-08-27 20:26
Peer-Review Started	2016-08-31 18:56
To Make the First Decision	2016-10-20 13:00
Return for Revision	2016-10-21 10:54
Revised	2016-11-17 00:00
Second Decision	2016-12-01 12:12
Accepted by Journal Editor-in-Chief	2016-12-02 10:45
Accepted by Executive Editor-in-Chief	2016-12-08 15:38
Articles in Press	2016-12-08 15:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-05 20:53
Publish the Manuscript Online	2017-01-22 11:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Editorial
Article Title	Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Youssef Alhmada, Denis Selimovic, Fadi Murad, Sarah-Lilly Hassan, Youssef Haikel, Mossaad Megahed, Matthias Hannig and Mohamed Hassan
Funding Agency and Grant Number
Corresponding Author	Dr. Mohamed Hassan, Department of Surgery, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States. dr.hassan@gmx.de
Key Words	Hepatitis C virus; Pruritus; Cholestasis; Autotoxin; Lysophosphatidic acid; PI3 kinase
Core Tip	Pruritus is a frequent symptom of chronic liver diseases. Chronic hepatitis C virus (HCV) infection can cause pruritus through both direct and indirect mechanisms. The direct mechanisms include induction of pro-inflammatory cytokines and chemokines as a consequence of the chronic HCV infection. Indirect mechanisms are associated with HCV-induced cholestasis leading to the accumulation of autotaxin, which is responsible for the conversion of lysophosphatidic choline into lysophosphatidic acid. This stimulates epidermal nerve endings leading to pruritus.
Publish Date	2017-01-22 11:39
Citation	Alhmada Y, Selimovic D, Murad F, Hassan SL, Haikel Y, Megahed M, Hannig M, Hassan M. Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies. World J Gastroenterol 2017; 23(5): 743-750
URL	http://www.wjgnet.com/1007-9327/full/v23/i5/743.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i5.743

Full Article (PDF)	WJG-23-743.pdf
Full Article (Word)	WJG-23-743.doc
Manuscript File	29773-Review.doc
Answering Reviewers	29773-Answering reviewers.pdf
Audio Core Tip	29773-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	29773-Conflict-of-interest statement.pdf
Copyright License Agreement	29773-Copyright assignment.pdf
Peer-review Report	29773-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29773-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29773-Scientific misconduct check.pdf
Scientific Editor Work List	29773-Scientific editor work list.pdf