Publication Name	World Journal of Gastroenterology
Manuscript ID	29776
Country	Italy

Received	2016-08-27 20:32
Peer-Review Started	2016-08-31 19:08
To Make the First Decision	2016-11-09 08:16
Return for Revision	2016-11-11 16:31
Revised	2016-11-18 19:19
Second Decision	2016-12-09 17:42
Accepted by Journal Editor-in-Chief	2016-12-09 18:11
Accepted by Executive Editor-in-Chief	2016-12-19 17:17
Articles in Press	2016-12-19 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-23 21:51
Publish the Manuscript Online	2017-01-14 10:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Microbiology
Manuscript Type	Minireviews
Article Title	Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia
Manuscript Source	Invited Manuscript
All Author List	Claudia Sisa, Silvia Turroni, Roberto Amici, Patrizia Brigidi, Marco Candela and Matteo Cerri
Funding Agency and Grant Number
Corresponding Author	Marco Candela, PhD, Unit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marco.candela@unibo.it
Key Words	Therapeutic hypothermia; Gut microbiota; Hibernation; Dysbiosis; Synthetic torpor
Core Tip	Therapeutic hypothermia is currently limited by several factors, including the patient compensatory response. Recently, the possibility to induce synthetic torpor in non-hibernators has opened new scenarios, but a deep understanding of torpor and hibernation physiology is required. One particular aspect to consider is the gut microbiota (GM). In hibernators, the GM undergoes seasonal shifts, as a physiological response to the body temperature drop, and is considered playing a central role in regulating physiology, specifically influencing the immune system. Since the GM changes induced by synthetic torpor have never been described in non-hibernators, possible risks and reasonable interventions are suggested.
Publish Date	2017-01-14 10:27
Citation	Sisa C, Turroni S, Amici R, Brigidi P, Candela M, Cerri M. Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia. World J Gastroenterol 2017; 23(3): 406-413
URL	http://www.wjgnet.com/1007-9327/full/v23/i3/406.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i3.406

Full Article (PDF)	WJG-23-406.pdf
Full Article (Word)	WJG-23-406.doc
Manuscript File	29776-Review.docx
Answering Reviewers	29776-Answering reviewers.pdf
Audio Core Tip	29776-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29776-Conflict-of-interest statement.pdf
Copyright License Agreement	29776-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29776-Language certificate.pdf
Peer-review Report	29776-Peer-reivew(s).pdf
Journal Editor-in-Chief Review Report	29776-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29776-Scientific misconduct check.pdf
Scientific Editor Work List	29776-Scientific editor work list.pdf