Publication Name	World Journal of Biological Chemistry
Manuscript ID	29778
Country	Brazil

Received	2016-08-27 20:41
Peer-Review Started	2016-08-29 08:36
To Make the First Decision	2016-11-11 09:29
Return for Revision	2016-11-14 16:58
Revised	2016-12-30 00:00
Second Decision	2017-01-04 16:04
Accepted by Journal Editor-in-Chief	2017-01-05 01:00
Accepted by Executive Editor-in-Chief	2017-01-14 14:03
Articles in Press	2017-01-14 14:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-21 18:20
Publish the Manuscript Online	2017-02-25 15:11

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Chemistry, Medicinal
Manuscript Type	Review
Article Title	Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
Manuscript Source	Invited Manuscript
All Author List	Vitor Sueth-Santiago, Debora Decote-Ricardo, Alexandre Morrot, Celio Geraldo Freire-de-Lima and Marco Edilson Freire Lima
Funding Agency and Grant Number
Corresponding Author	Dr. Marco Edilson Freire Lima, Univer­sidade Federal Rural do Rio de Janeiro, Instituto de Ciências Exatas, Departamento de Química, Rodovia BR 465, Km 7, Seropédica, CEP 23890-000, Brazil. marco@ufrrj.br
Key Words	Trypanosoma cruzi; Trans-sialidase; Trypanothione reductase; CYP51; Cruzipain; Tubulin
Core Tip	Chagas disease remains the most neglected parasitic illness the world. Here, we note that detailed knowledge of both the differences and similarities between the Trypanosoma cruzi parasite and the human host’s biochemical targets may be the key to developing novel effective drugs to treat patients who are suffering with this severe and debilitating sickness.
Publish Date	2017-02-25 15:11
Citation	Sueth-Santiago V, Decote-Ricardo D, Morrot A, Freire-de-Lima CG, Lima MEF. Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host. World J Biol Chem 2017; 8(1): 57-80
URL	http://www.wjgnet.com/1949-8454/full/v8/i1/57.htm
DOI	http://dx.doi.org/10.4331/wjbc.v8.i1.57

Full Article (PDF)	WJBC-8-57.pdf
Full Article (Word)	WJBC-8-57.doc
Manuscript File	29778-Review.doc
Answering Reviewers	29778-Answering reviewers.pdf
Audio Core Tip	29778-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	29778-Conflict-of-interest statement.pdf
Copyright License Agreement	29778-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29778-Language certificate.pdf
Peer-review Report	29778-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29778-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29778-Scientific misconduct check.pdf
Scientific Editor Work List	29778-Scientific editor work list.pdf