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Articles Published Processes
5/18/2017 4:11:31 AM | Browse: 1264 | Download: 2313
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Received |
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2016-08-27 20:44 |
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Peer-Review Started |
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2016-08-29 08:38 |
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To Make the First Decision |
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2016-11-11 09:00 |
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Return for Revision |
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2016-11-17 09:04 |
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Revised |
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2016-12-16 07:52 |
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Second Decision |
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2017-03-07 15:27 |
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Accepted by Journal Editor-in-Chief |
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2017-03-08 01:03 |
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Accepted by Executive Editor-in-Chief |
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2017-03-17 14:07 |
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Articles in Press |
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2017-03-17 14:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-16 01:42 |
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Publish the Manuscript Online |
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2017-05-18 04:11 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
B-1 cells modulate the murine macrophage response to Leishmania major infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Angelica F Arcanjo, Marise P Nunes, Elias B Silva-Junior, Monique Leandro, Juliana Dutra Barbosa da Rocha, Alexandre Morrot, Debora Decote-Ricardo and Celio Geraldo Freire-de-Lima |
| Funding Agency and Grant Number |
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| Corresponding Author |
Celio Geraldo Freire-de-Lima, PhD, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Bloco G, Room C1-015, Ilha do Fundao, Rio de Janeiro 21941-902, Brazil. celio@biof.ufrj.br |
| Key Words |
Leishmania major; Macrophages; B-1 cells; Interleukin-10; Prostaglandin E2; Infection |
| Core Tip |
This original manuscript describes the modulatory effect of B-1 cells on Leishmania major-infected macrophages. We demonstrated the participation of soluble mediators in a co-culture system and characterized prostaglandin E2 and interleukin-10 (IL-10) as key factors involved in increased intracellular parasite replication. We also demonstrated that cell-cell contact is not important. The same effect was not observed when we used B-1 cells from IL-10 knockout mice, as no significant difference in parasite multiplication was observed. Thus, the current manuscript may be of interest for scientists working in the fields of immunoparasitology or immunomodulation. |
| Publish Date |
2017-05-18 04:11 |
| Citation |
Arcanjo AF, Nunes MP, Silva-Junior EB, Leandro M, Rocha JDB, Morrot A, Decote-Ricardo D, Freire-de-Lima CG. B-1 cells modulate the murine macrophage response to Leishmania major infection. World J Biol Chem 2017; 8(2): 151-162 |
| URL |
http://www.wjgnet.com/1949-8454/full/v8/i2/151.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v8.i2.151 |
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