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5/18/2017 4:11:31 AM | Browse: 456 | Download: 640
Publication Name World Journal of Biological Chemistry
Manuscript ID 29780
Country/Territory Brazil
2016-08-27 20:44
Peer-Review Started
2016-08-29 08:38
To Make the First Decision
2016-11-11 09:00
Return for Revision
2016-11-17 09:04
2016-12-16 07:52
Second Decision
2017-03-07 15:27
Accepted by Journal Editor-in-Chief
2017-03-08 01:03
Accepted by Company Editor-in-Chief
2017-03-17 14:07
Articles in Press
2017-03-17 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-16 01:42
Publish the Manuscript Online
2017-05-18 04:11
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Basic Study
Article Title B-1 cells modulate the murine macrophage response to Leishmania major infection
Manuscript Source Invited Manuscript
All Author List Angelica F Arcanjo, Marise P Nunes, Elias B Silva-Junior, Monique Leandro, Juliana Dutra Barbosa da Rocha, Alexandre Morrot, Debora Decote-Ricardo and Celio Geraldo Freire-de-Lima
Funding Agency and Grant Number
Corresponding author Celio Geraldo Freire-de-Lima, PhD, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Bloco G, Room C1-015, Ilha do Fundao, Rio de Janeiro 21941-902, Brazil. celio@biof.ufrj.br
Key Words Leishmania major; Macrophages; B-1 cells; Interleukin-10; Prostaglandin E2; Infection
Core Tip This original manuscript describes the modulatory effect of B-1 cells on Leishmania major-infected macrophages. We demonstrated the participation of soluble mediators in a co-culture system and characterized prostaglandin E2 and interleukin-10 (IL-10) as key factors involved in increased intracellular parasite replication. We also demonstrated that cell-cell contact is not important. The same effect was not observed when we used B-1 cells from IL-10 knockout mice, as no significant difference in parasite multiplication was observed. Thus, the current manuscript may be of interest for scientists working in the fields of immunoparasitology or immunomodulation.
Publish Date 2017-05-18 04:11
Citation Arcanjo AF, Nunes MP, Silva-Junior EB, Leandro M, Rocha JDB, Morrot A, Decote-Ricardo D, Freire-de-Lima CG. B-1 cells modulate the murine macrophage response to Leishmania major infection. World J Biol Chem 2017; 8(2): 151-162
Url http://www.wjgnet.com/1949-8454/full/v8/i2/151.htm
DOI http://dx.doi.org/10.4331/wjbc.v8.i2.151
Full Article (PDF) WJBC-8-151.pdf
Full Article (Word) WJBC-8-151.doc
Manuscript File 29780-Review.doc
Answering Reviewers 29780-Answering reviewers.pdf
Audio Core Tip 29780-Audio core tip.m4a
Biostatistics Review Certificate 29780-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 29780-Conflict-of-interest statement.pdf
Copyright License Agreement 29780-Copyright assignment.pdf
Data Sharing Statement 29780-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 29780-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 29780-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29780-Language certificate.pdf
Scientific Research Process 29780-Scientific research process.pdf
Peer-review Report 29780-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 29780-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 29780-Scientific misconduct check.pdf
Scientific Editor Work List 29780-Scientific editor work list.pdf