Publication Name	World Journal of Experimental Medicine
Manuscript ID	29787
Country	United States

Received	2016-08-27 20:58
Peer-Review Started	2016-08-29 19:33
To Make the First Decision	2016-11-11 09:29
Return for Revision	2016-11-14 17:02
Revised	2016-11-19 02:11
Second Decision	2016-11-29 09:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-09 17:33
Articles in Press	2016-12-09 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-09 15:06
Publish the Manuscript Online	2017-02-17 10:11

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Effect of aging on stem cells
Manuscript Source	Invited Manuscript
All Author List	Abu Shufian Ishtiaq Ahmed, Matilda HC Sheng, Samiksha Wasnik, David J Baylink and Kin-Hing William Lau
Funding Agency and Grant Number	Funding Agency Grant Number None
Corresponding Author	Kin-Hing William Lau, PhD, Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, United States. william.lau@med.va.gov
Key Words	Aging; Biological aging; Cellular aging; Adult stem cells; Premature aging; Mesenchymal stem cell; Stem cell renewal; Tissue regeneration
Core Tip	Stem cells have the remarkable self-renewal capability and the amazing ability to differentiate into all cell types. It is generally believe that stem cells are the main source that provides cells to repair and re?generate damaged tissues and organs. However, there is now compelling evidence that the aging process has a deleterious effect on stem cells, and that the aging effects on stem cells may have play essential roles in the pathophysiology of the various aging-associated diseases. This review discusses briefly the relationship of aging-associated stem cell dysfunction and the various aging-associated ailments, and several proposed concepts on the molecular mechanism of aging-related stem cell dysfunction.
Publish Date	2017-02-17 10:11
Citation	Ahmed ASI, Sheng MHC, Wasnik S, Baylink DJ, Lau KHW. Effect of aging on stem cells. World J Exp Med 2017; 7(1): 1-10
URL	http://www.wjgnet.com/2220-315X/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.5493/wjem.v7.i1.1

Full Article (PDF)	WJEM-7-1.pdf
Full Article (Word)	WJEM-7-1.doc
Manuscript File	29787-Review.doc
Answering Reviewers	29787-Answering reviewers.pdf
Audio Core Tip	29787-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29787-Conflict-of-interest statement.pdf
Copyright License Agreement	29787-Copyright assignment.pdf
Peer-review Report	29787-Peer-review(s).pdf
Scientific Misconduct Check	29787-Scientific misconduct check.pdf
Scientific Editor Work List	29787-Scientific editor work list.pdf