Publication Name	World Journal of Clinical Urology
Manuscript ID	29852
Country	Spain

Received	2016-08-29 20:09
Peer-Review Started	2016-09-01 10:13
First Decision by Editorial Office Director
Return for Revision	2016-12-14 10:41
Revised	2016-12-19 19:20
Publication Fee Transferred
Second Decision by Editor	2017-02-16 17:40
Second Decision by Editor-in-Chief	2017-02-17 16:05
Final Decision by Editorial Office Director	2017-03-13 12:21
Articles in Press	2017-03-13 12:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-18 09:03
Publish the Manuscript Online	2017-07-21 02:57

ISSN	2219-2816 (online)
Open Access	This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt and build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Recirculating chemohyperthermia as a treatment for non-muscle invasive bladder cancer: Current and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Javier Flores-Carbajal, Alejandro Sousa-Escandón, Daniel Sousa-Gonzalez, Silvia Rodriguez Gomez, Manuel Lopez Saavedra and M Elia Fernandez Martinez
Funding Agency and Grant Number
Corresponding Author	Alejandro Sousa-Escandón, Chief of Service, Comarcal Hospital of Monforte, Curros Enriquez St. 41, 27400 Monforte-Lugo, Spain. sousa-alejandro@hotmail.com
Key Words	Bladder cancer; Thermotherapy; Non-muscle invasive; Chemohyperthermia; Recirculating; Intravesical chemotherapy; Treatment; Mechanism of action
Core Tip	Chemohyperthermia has demonstrated a selective cytotoxicity on tumoral cells without affecting the remaining healthy cells and it significantly increases the penetration of MMC during intravesical instillations. Moreover, hyperthermia and many chemotherapeutic agents have a synergistic effect, significantly reducing the relative risk of tumoral recurrence in patients non-muscle invasive bladder cancer. Recirculative systems are a novel way to apply endovesical chemohyperthermia, which achieves excellent clinical results with a better side effects profile and a lower price than the one of other chemohyperthermia technologies.
Publish Date	2017-07-21 02:57
Citation	Flores-Carbajal J, Sousa-Escandón A, Sousa-Gonzalez D, Rodriguez Gomez S, Lopez Saavedra M, Fernandez Martinez ME. Recirculating chemohyperthermia as a treatment for non-muscle invasive bladder cancer: Current and future perspectives. World J Clin Urol 2017; 6(2): 34-39
URL	http://www.wjgnet.com/2219-2816/full/6/i2/34.htm
DOI	http://dx.doi.org/10.5410/wjcu.v6.i2.34

Full Article (PDF)	WJCU-6-34.pdf
Full Article (Word)	WJCU-6-34.doc
Manuscript File	29852-Review.docx
Answering Reviewers	29852-Answering reviewers.pdf
Audio Core Tip	29852-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	29852-Conflict-of-interest statement.pdf
Copyright License Agreement	29852-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20160828195254.docx
Peer-review Report	29852-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29852-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29852-Scientific misconduct check.pdf
Scientific Editor Work List	29852-Scientific editor work list.pdf