Publication Name	World Journal of Hematology
Manuscript ID	29882
Country	United Kingdom

Received	2016-08-29 13:36
Peer-Review Started	2016-09-01 10:57
To Make the First Decision	2016-10-20 08:46
Return for Revision	2016-10-31 09:11
Revised	2016-11-08 01:11
Second Decision	2016-12-12 08:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-19 10:56
Articles in Press	2016-12-19 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-10 11:42
Publish the Manuscript Online	2017-01-19 08:03

ISSN	2218-6204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Hematology
Manuscript Type	Basic Study
Article Title	Intestinal heme absorption in hemochromatosis gene knock-out mice
Manuscript Source	Invited Manuscript
All Author List	Abas H Laftah, Robert J Simpson and Gladys O Latunde-Dada
Funding Agency and Grant Number
Corresponding Author	Gladys O Latunde-Dada, PhD, Lecturer, Faculty of Life Sciences and Medicine, Division of Diabetes and Nutritional Sciences, King’s College London, Franklin Wilkins Building, 150 Stanford Street, London SE1 9NH, United Kingdom. yemisi.latunde-dada@kcl.ac.uk
Key Words	Hemochromatosis gene; Heme; Gavage; Iron; Absorption
Core Tip	These results indicate that loss of hemo-chromatosis gene (Hfe) protein results in increased dietary heme iron absorption that further contributes to the iron loading of the liver and other tissues of mice. Enhanced heme iron intake by homozygous Hfe subjects may contribute to body iron overload and early manifestation of phenotypic traits. This may have implications for dietary recommendations on heme intake by hemochromatosis subjects to avert tissue iron loading.
Publish Date	2017-01-19 08:03
Citation	Laftah AH, Simpson RJ, Latunde-Dada GO. Intestinal heme absorption in hemochromatosis gene knock-out mice. World J Hematol 2017; 6(1): 17-23
URL	http://www.wjgnet.com/2218-6204/full/v6/i1/17.htm
DOI	http://dx.doi.org/10.5315/wjh.v6.i1.17

Full Article (PDF)	WJH-6-17.pdf
Full Article (Word)	WJH-6-17.doc
Manuscript File	29882-Review.docx
Answering Reviewers	29882-Answering reviewers.pdf
Audio Core Tip	29882-Audio core tip.mp3
Biostatistics Review Certificate	29882-Biostatistics statement.pdf
Clinical Trial Registration Statement	29882-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	29882-Conflict-of-interest statement.pdf
Copyright License Agreement	29882-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	Grant_Application_Form_20160829021329.pdf
Signed Informed Consent Form(s) or Document(s)	29882-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	29882-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	29882-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29882-Language certificate.pdf
Peer-review Report	29882-Peer-review(s).pdf
Scientific Misconduct Check	29882-Scientific misconduct check.pdf
Scientific Editor Work List	29882-Scientific editor work list.pdf